Toshihiko Ono

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BACKGROUND Patients with diabetic nephropathy are likely to have neurological complications including cardiovascular autonomic dysfunction, which is related to increased risk of mortality. We investigated whether cardiovascular autonomic neuropathy is associated with left ventricular hypertrophy (LVH) in diabetic haemodialysis patients. METHODS Holter(More)
The effects of divalent cation ionophores, A23187 and X-537A, on the electrical membrane properties were investigated by using the soma membrane of the X-organ of the crayfish. They reduced the amplitude and maximum rate of rise of Ca-action potential in lower concentration. As the concentration increased, a reduction of membrane resistance and(More)
BACKGROUND S100A12 is an endogenous ligand of the receptor for advanced glycation end products (RAGE). Plasma S100A12 levels are high in end-stage renal disease (ESRD) patients undergoing maintenance hemodialysis (HD). Peripheral arterial disease (PAD) is common in HD patients and is associated with increased cardiovascular morbidity and mortality rates in(More)
We investigated whether chronic intravenous administration of l-carnitine could improve myocardial fatty acid imaging in patients on maintenance hemodialysis. We enrolled 72 hemodialysis patients who had impaired myocardial fatty acid imaging and left ventricular dysfunction not based on coronary lesion. l-Carnitine (1,000 mg) was intravenously administered(More)
PURPOSE We investigated whether impaired patterns of myocardial fatty acid imaging were associated with cardiac death in dialysis patients without coronary lesions. METHODS We prospectively enrolled 155 hemodialysis patients without obstructive coronary artery disease, who had been examined by single-photon emission computed tomography (SPECT) using the(More)
This paper proposes a basic theory on physical reality and a new foundation for quantum mechanics and classical mechanics. It does not only solve the problem of the arbitrariness on the operator ordering for the quantization procedure, but also clarifies how the classical-limit occurs. This paper is the first of the three papers into which the previous(More)
This paper proposes a basic theory on the physical reality, and a new foundation for quantum mechanics and classical mechanics. It does not only solve the problem of the arbitrariness on the operator ordering for the quantization procedure, but also clarifies how the classical-limit occurs. It further compares the new theory with the known quantization(More)
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