Toshihiko Morikawa

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AIM Antenatal stress, maturation and other foetal conditions affect the postnatal cardiovascular function. Atrial- (ANP) and brain-type natriuretic peptide (BNP) play important roles in regulating extracellular fluid volume and blood pressure, which may surrogate the foetal cardiovascular condition. The aim of this study was to investigate the dependence of(More)
There are numerous alternatives to the so-called Bonferroni adjustment to control for familywise Type I error among multiple tests. Yet, for the most part, these approaches disregard the correlation among endpoints. This can prove to be a conservative hypothesis testing strategy if the null hypothesis is false. The James procedure was proposed to account(More)
Clinical trials that aim to establish efficacy in the target population need to have an adequate control group. Although scientific principles for efficacy evaluation apply universally, actual choices of control in each region seem to be unique, reflecting differences in regional guidelines for clinical evaluation, preferences of the population, and(More)
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