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  • Toshihiko Kasahara, Kazuo Tomita, +5 authors Chihaya Kakinuma
  • Medicine, Biology
  • Toxicological sciences : an official journal of…
  • 2006 (First Published: 1 March 2006)
  • Excessive accumulation of phospholipids results in phospholipidosis (PL), which may interfere with cellular functions, leading to acute or chronic disease or even death. Electron-microscopicContinue Reading
  • Shun Matsuda, Sayaka Wanibuchi, Toshihiko Kasahara
  • Biology, Medicine
  • Mutagenesis
  • 2018 (First Published: 31 December 2018)
  • Ser139-phosphorylated H2AX (γH2AX) is a functional biomarker of DNA double-strand breaks. However, its conventional detection for in vivo samples relies on immunological methods using anti-γH2AXContinue Reading
  • Morihiko Hirota, Shiho Fukui, +14 authors Masaaki Miyazawa
  • Chemistry, Medicine
  • Journal of applied toxicology : JAT
  • 2015 (First Published: 1 November 2015)
  • The skin sensitization potential of chemicals has been determined with the use of the murine local lymph node assay (LLNA). However, in recent years public concern about animal welfare has led to aContinue Reading
  • Masaharu Fujita, Yusuke Yamamoto, Sayaka Wanibuchi, Yasuhiro Katsuoka, Toshihiko Kasahara
  • Biology, Medicine
  • Toxicology in vitro : an international journal…
  • 2019 (First Published: 1 September 2019)
  • The Amino acid Derivative Reactivity Assay (ADRA) is an in chemico alternative to animal testing for skin sensitization potential, in which measurements of multi-constituent solutions were sometimesContinue Reading
  • Miyuki Akimoto, Yusuke Yamamoto, +14 authors Masaharu Fujita
  • Medicine
  • Journal of applied toxicology : JAT
  • 2020 (First Published: 12 February 2020)
  • The amino acid derivative reactivity assay (ADRA), which is an in chemico alternative to the use of animals in testing for skin sensitization potential, offers significant advantages over the directContinue Reading