Toshihide Muramatsu

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Midkine (MK) is a heparin-binding growth factor and is frequently expressed at high levels in many human carcinomas. To investigate further the roles of MK in the regulation of cell growth, we introduced MK expression in NIH3T3 cells. A mixture of transfectants of an MK expression vector, but not a control vector, formed colonies in soft agar, showed an(More)
Midkine (MK) is a growth factor identified as a product of a retinoic acid-responsive gene. A truncated form of MK mRNA, which lacks a sequence encoding the N-terminally located domain, was recently found in cancer cells. We investigated the expression of the truncated MK mRNA in specimens of 47 surgically removed human gastrointestinal organs using(More)
  • T. Muramatsu, Y. Yamashina, T. Shirai, T. Ohnishi
  • 1994
Pemphigus and bullous pemphigoid (BP) are autoimmune bullous diseases of the skin and mucous membranes. Although the aetiology of pemphigus and BP has not been completely determined, there have been some reports on the factors inducing these diseases [1, 4, 17]. Ionizing radiation [6, 11] and ultraviolet (UV) radiation have been recognized as factors(More)
  • T. Muramatsu, N. Kobayashi, +4 authors T. Ohnishi
  • 1992
To examine the induction and repair of UV-induced DNA damage, indirect immunofluorescence was performed on UVB-irradiated organ-cultured normal human skin using monoclonal antibodies specific for either cyclobutane pyrimidine dimers or (6-4) photoproducts. Nuclear immunofluorescence of cyclobutane pyrimidine dimers and (6-4) photoproducts were observed in a(More)
  • T. Muramatsu, T. Shirai, T. Iida, Y. Yamashina, K. Sakamoto
  • 1988
To clarify the antigen specificities of autoantibodies in sera and blister fluids from patients diagnosed as bullous pemphigoid (BP) by routine histology and immunofluorescence (IF) methods, indirect IF studies using the salt split-skin technique were performed. In addition, to detect the BP antigen(s) in human epidermal extracts, Western immunoblotting(More)
  • T. Muramatsu, S. Matsushita, H. Arai, H. Sasaki, S. Higuchi
  • 2005
α1-Antichymotrypsin (ACT), a component of the senile plaque of the Alzheimer's disese (AD) brain, has a possible role as a molecular chaper-one in developing AD pathology. This study was a search for the possible association of the two structural polymorphisms of ACT, Ala15 → Thr and Met389 → Val in the Japanese population. In 101 AD patients, genotype and(More)
Non-alcoholic steatohepatitis (NASH) has emerged as a common cause of chronic liver disease and virus-independent hepatocellular carcinoma (HCC) in patients with obesity, diabetes, and metabolic syndrome. To reveal the molecular mechanism underlying hepatocarcinogenesis from NASH, microRNA (miRNA) expression profiles were analyzed in STAM mice, a NASH-HCC(More)
The histone deacetylase (HDAC) inhibitor suberoylanilide hydroxamic acid (SAHA) has a clinical promise for treatment of cancer including hepatocellular carcinoma (HCC). To investigate effect of SAHA on hepatitis C virus (HCV) replication, we treated the HCV replicon cell OR6 with SAHA. HCV replication was significantly inhibited by SAHA at concentrations(More)
  • Y. Suzuki, T. Muramatsu, +7 authors K. Matsuoka
  • 1996
To investigate the influence of the mitochondrial aldehyde dehydrogenase 2 (ALDH2) genotype on the clinical features of diabetes, 212 Japanese patients with non-insulin-dependent diabetes mellitus (NIDDM) (154 males and 58 females aged 17–83 years; mean age 58.2 years) were investigated. Genotyping of ALDH2 was performed by the polymerase chain reaction —(More)
Recent studies have proposed that the major anti-tumor effect of DNA methylation inhibitors is induction of interferon-responsive genes via dsRNAs-containing endogenous retroviruses. Recently, a 3D culture system for stem cells known as organoid culture has been developed. Lgr5-positive stem cells form organoids that closely recapitulate the properties of(More)