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  • Mark J. Kiel, Ömer H. Yilmaz, Toshihide Iwashita, Osman Yilmaz, Cox Terhorst, Sean J Morrison
  • Biology, Medicine
  • Cell
  • 2005 (First Publication: 1 July 2005)
  • To improve our ability to identify hematopoietic stem cells (HSCs) and their localization in vivo, we compared the gene expression profiles of highly purified HSCs and non-self-renewing multipotentContinue Reading
  • Anna V Molofsky, Ricardo Pardal, Toshihide Iwashita, In-kyung Park, Michael F. Clarke, Sean J Morrison
  • Biology, Medicine
  • Nature
  • 2003 (First Publication: 1 October 2003)
  • Stem cells persist throughout life by self-renewing in numerous tissues including the central and peripheral nervous systems. This raises the issue of whether there is a conserved mechanism to effectContinue Reading
  • Genevieve M. Kruger, Jack T. Mosher, Suzanne Bixby, Nancy M. Joseph, Toshihide Iwashita, Sean J Morrison
  • Biology, Medicine
  • Neuron
  • 2002 (First Publication: 1 August 2002)
  • We found neural crest stem cells (NCSCs) in the adult gut. Postnatal gut NCSCs were isolated by flow-cytometry and compared to fetal gut NCSCs. They self-renewed extensively in culture but less thanContinue Reading
  • Shenghui He, Toshihide Iwashita, Johanna Buchstaller, Anna V Molofsky, Dafydd Gareth Thomas, Sean J Morrison
  • Medicine, Biology
  • Developmental biology
  • 2009 (First Publication: 1 April 2009)
  • The polycomb gene Bmi-1 is required for the self-renewal of stem cells from diverse tissues, including the central nervous system (CNS). Bmi-1 expression is elevated in most human gliomas,Continue Reading
  • Mark J. Kiel, Toshihide Iwashita, Omer H. Yilmaz, Sean J Morrison
  • Biology, Medicine
  • Developmental biology
  • 2005 (First Publication: 1 July 2005)
  • Most tissues are patterned so that progenitors in different locations are programmed to have different properties. Stem cells from different regions of the nervous system acquire intrinsicContinue Reading
  • Takeharu Kanazawa, Pavan K. Kommareddi, +7 authors Thomas E. Carey
  • Medicine, Biology
  • Clinical Cancer Research
  • 2009 (First Publication: 10 March 2009)
  • Purpose: Galanin and its three receptors (GALR1-3) are expressed in many normal tissues, but silenced in some tumors. Contradictory roles for galanin and its receptors in various tumors have beenContinue Reading
  • Kayoko Matsumura, Hiroshi Nakase, +8 authors Tsutomu Chiba
  • Medicine
  • Inflammatory bowel diseases
  • 2013 (First Publication: 1 July 2013)
  • BACKGROUND Human cytomegalovirus (HCMV) infection is considered to be an exacerbating factor in patients with ulcerative colitis (UC). However, the pathogenicity of HCMV in the exacerbation of UCContinue Reading