Toshiharu Tsuda

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In association with the international validation project to establish an OECD Enhanced Test Guideline 407, we performed a 28-day repeated-dose toxicity study of genistein, which is known as a phytoestrogen. Attention was paid to the sensitivity of certain additional parameters, such as histopathology observations and organ weights of endocrine related(More)
In association with the international validation project to establish an OECD Enhanced Test Guideline 407, we performed a 28-day repeated-dose toxicity study of methoxychlor, a chlorinated hydrocarbon pesticide with pro-estrogenic and anti-androgenic activities. Attention was paid to the sensitivity of certain additional parameters for detecting endocrine(More)
The purpose of this study was to quantify the uptake and excretion of Tc-99m-N-pyridoxyl-5-methyltryptophan (PMT) by hepatocytes using a tracer kinetic modeling approach, and to clarify the pathophysiological changes of diffuse parenchymal liver diseases. Fifty-two patients with liver diseases and seven normal subjects were studied. Studies were performed(More)
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