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  • Yoshihisa Shitara, Kazuya Maeda, Kazuaki Ikejiri, Kenta Yoshida, Toshiharu Horie, Yuichi Sugiyama
  • Medicine, Chemistry
  • Biopharmaceutics & drug disposition
  • 2013
  • Organic anion transporting polypeptide (OATP) family transporters accept a number of drugs and are increasingly being recognized as important factors in governing drug and metaboliteExpand
  • Eiichiro Ogimura, S. Sekine, T. Horie
  • Chemistry, Medicine
  • Biochemical and biophysical research…
  • 2011 (First Publication: 16 December 2011)
  • Drug-induced liver injury (DILI) is a major reason for the dropout of candidate compounds from drug testing and the withdrawal of pharmaceuticals from clinical use. Among the various mechanisms ofExpand
  • José C Fernández-Checa, Hirosato Takikawa, Toshiharu Horie, Murad Ookhtens, Neil Kaplowitz
  • Chemistry, Medicine
  • The Journal of biological chemistry
  • 1992 (First Publication: 25 January 1992)
  • We have characterized the transport of GSH and the mechanism for impaired GSH transport in mutant Eisai hyperbilirubinemic rats (EHBR) using isolated canalicular membrane-enriched vesicles (cLPM). InExpand
  • Hirokazu Doi, Hiromi Iwasaki, Yasuhiro Masubuchi, Ryuichiro Nishigaki, Toshiharu Horie
  • Chemistry, Medicine
  • Chemico-biological interactions
  • 2002 (First Publication: 1 May 2002)
  • Rat liver microsomal suspension (1 mg protein per ml) was incubated at 37 degrees C with 5 mM salicylic acid and 0.2 mM NADPH. The amounts of thiobarbituric acid reactive substances (TBARS) andExpand
  • Masaya Tachibana, Makoto Tanaka, Yasuhiro Masubuchi, Toshiharu Horie
  • Chemistry, Medicine
  • Drug Metabolism and Disposition
  • 2005 (First Publication: 1 June 2005)
  • Acyl glucuronidation is an important metabolic pathway for fluoroquinolone antibiotics. However, it is unclear which human UDP-glucuronosyltransferase (UGT) enzymes are involved in theExpand