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  • Toshifumi Nomura, Aileen Sandilands, +11 authors Hiroshi Shimizu
  • Biology, Medicine
  • The Journal of allergy and clinical immunology
  • 2007 (First Published: 1 February 2007)
  • BACKGROUND Filaggrin is a key protein involved in skin barrier function. Recently, mutations in the filaggrin gene, FLG, were identified in European families with ichthyosis vulgaris (IV) and shownContinue Reading
  • Ikue Nemoto-Hasebe, Masashi Akiyama, Toshifumi Nomura, Aileen Sandilands, W H I Mclean, Hiroshi Shimizu
  • Medicine
  • The Journal of investigative dermatology
  • 2009 (First Published: 1 March 2009)
  • Mutations in the gene-encoding filaggrin (FLG), a key molecule involved in skin barrier function, have been shown to be a major predisposing factor for atopic dermatitis (AD; eczema). To elucidateContinue Reading
  • Toshifumi Nomura, Masashi Akiyama, +9 authors W H Irwin McLean
  • Biology, Medicine
  • The Journal of investigative dermatology
  • 2008 (First Published: 1 June 2008)
  • Mutations in the gene encoding filaggrin (FLG) have been identified as the cause of ichthyosis vulgaris (IV) and shown to be major predisposing factors for atopic dermatitis (AD). However, theseContinue Reading
  • Rieko Kabashima-Kubo, Motonobu Nakamura, +12 authors Yoshiki Tokura
  • Biology, Medicine
  • Journal of dermatological science
  • 2012 (First Published: 1 July 2012)
  • BACKGROUND Atopic dermatitis (AD) can be classified into the major extrinsic type with high serum IgE levels and impaired barrier, and the minor intrinsic type with normal IgE levels and unimpairedContinue Reading