Toshiaki Miyazaki

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Adiponectin, a major adipose cytokine, plays a crucial role in the inhibition of metabolic syndrome by acting on such cell types as muscle cells and hepatocytes. Furthermore, evidence suggests that adiponectin may influence cancer pathogenesis. Adiponectin occurs in non-proteolytic (full-length adiponectin: f-adiponectin) and proteolytic (globular(More)
Engaging inhibitory FcγRIIb by Fc region has been recently reported to be an attractive approach for improving the efficacy of antibody therapeutics. However, the previously reported S267E/L328F variant with enhanced binding affinity to FcγRIIb, also enhances binding affinity to FcγRIIa(R131) allotype to a similar degree because FcγRIIb and FcγRIIa(R131)(More)
After a decade of extensive research on application-specific wireless sensor networks (WSNs), the recent development of information and communication technologies make it practical to realize new WSNs paradigm known as software-defined sensor networks (SDSNs). SDSNs are able to adapt to various application requirements and to fully explore the(More)
We propose a software-defined wireless sensor network system whose behavior can be redefined even after deployment by the injection of sensor node roles by means of wireless network communications. Two main technologies are used to develop this system, role generation and delivery mechanism, and a reconfigurable wireless sensor network with many(More)
A function alternation mechanism is proposed. It enables sensor nodes to take over the damaged functions of their neighboring sensor nodes automatically. By introducing the mechanism in a wireless sensor network (WSN), we can realize a WSN that never stops monitoring, and does not require maintenance after it is deployed, even if some sensor nodes suddenly(More)
Prostate cancer is associated with obesity. However, the molecular basis of this association is not well known. Adiponectin is a major adipose cytokine that decreases in circulation in obesity and ameliorates obesity. Here, we identify adiponectin as a novel inhibitor in prostate cancer cell growth. Adiponectin occurs in non-proteolytic (full-length(More)
The dopamine D2/D3 receptor agonist pramipexole has clinically been proven to improve depression or treatment-resistant depression. However, the involvement of the dopamine receptor system on the effect of pramipexole on depression remains unclear. We examined the influence of pramipexole on the duration of immobility during the forced swim test in normal(More)
After a decade of extensive research on application-specific wireless sensor networks (WSNs), the recent development of information and communication technologies makes it practical to realize the software-defined sensor networks (SDSNs), which are able to adapt to various application requirements and to fully explore the resources of WSNs. A sensor node in(More)