Toshiaki Hiramatsu

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High mobility group box 1 (HMGB1), a ubiquitous nuclear protein, induces several inflammatory diseases and functions as a fatal factor when released extracellularly. The effect of HMGB1 on vascular reactivity during sepsis remains to be clarified. A rat model of abdominal sepsis was produced by cecal ligation and puncture (CLP) under sevoflurane anesthesia(More)
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