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NF-kappa B as a therapeutic target in multiple myeloma.
It is demonstrated that specific targeting of NF-kappaB can overcome the growth and survival advantage conferred both by tumor cell binding to BMSCs and cytokine secretion in the BM milieu.
NF-κB as a Therapeutic Target in Multiple Myeloma*
These studies demonstrate that specific targeting of NF-κB can overcome the growth and survival advantage conferred both by tumor cell binding to BMSCs and cytokine secretion in the BM milieu.
Molecular mechanisms whereby immunomodulatory drugs activate natural killer cells: clinical application
- Toshiaki Hayashi, T. Hideshima, K. Anderson
- Biology, MedicineBritish journal of haematology
- 1 January 2005
These studies defined the mechanisms whereby IMiDs trigger NK cell‐mediated tumour‐cell lysis, further supporting their therapeutic use in MM.
Steroid degradation in Comamonas testosteroni
Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341.
Molecular mechanisms whereby PS-341 mediates anti-MM activity are demonstrated by inducing p53 and MDM2 protein expression; inducing the phosphorylation (Ser15) of p53 protein; activating c-Jun NH(2)-terminal kinase (JNK), caspase-8, and caspases-3; and cleaving the DNA protein kinase catalytic subunit, ATM, andMDM2.
The biological sequelae of stromal cell-derived factor-1alpha in multiple myeloma.
It is demonstrated that SDF-1alpha promotes growth, migration and drug resistance of MM cells in the BM microenvironment, but these effects are only modest, and SDF -1alpha therefore does not represent a target for novel therapeutics in this disease.
A New Bacterial Steroid Degradation Gene Cluster in Comamonas testosteroni TA441 Which Consists of Aromatic-Compound Degradation Genes for Seco-Steroids and 3-Ketosteroid Dehydrogenase Genes
- M. Horinouchi, Toshiaki Hayashi, Takako Yamamoto, T. Kudo
- BiologyApplied and Environmental Microbiology
- 1 August 2003
These genes were shown to be induced when TA441 was incubated with steroids but not with aromatic compounds [phenol, biphenyl, and 3-(3-hydroxyphenyl)propionic acid], indicating that these genes function exclusively in steroid degradation.
Nuclear factor-kappaB p65 mediates tumor necrosis factor alpha-induced nuclear translocation of telomerase reverse transcriptase protein.
It is suggested that NF-kappaB p65 plays a pivotal role in regulating telomerase by modulating its nuclear translocation.
Nuclear Factor-κB p65 Mediates Tumor Necrosis Factor α-induced Nuclear Translocation of Telomerase Reverse Transcriptase Protein
It is suggested that NF- B p65 plays a pivotal role in regulating telomerase by modulating its nuclear translocation.
Value of serum IgG4 in the diagnosis of IgG4-related disease and in differentiation from rheumatic diseases and other diseases
The aim of this work was to re-evaluate the usual cut-off value in AIP (135 mg/dL) that is used to diagnose whole IgG4-RD in the setting of a rheumatic clinic by measuring serum Igg4 levels in IgG 4-RD and various disorders.