Toshiaki Goseki

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In order to clarify the vasodilatory mechanism of betaxolol and timolol, we studied the effects of these drugs in isolated rabbit ciliary arteries. Rabbit ciliary artery specimens were mounted in a double myograph system, and betaxolol, timolol, or another agent was introduced into the organ chamber. The mechanical response of the arteries was studied using(More)
PURPOSE To determine the mechanism of intraoperative floppy-iris syndrome (IFIS) by examining the binding affinity of tamsulosin and silodosin to α-receptors and melanin pigment using control and α(2)-blocker chronically administered in rabbit models. SETTING Department of Ophthalmology, Kitasato University School of Medicine, Kanagawa, Japan. DESIGN(More)
PURPOSE To assess the daytime variations in pupil size when far and near targets are viewed under photopic conditions. METHODS We prospectively examined 20 eyes of 20 healthy subjects [27.3 years ± 4.1 (SD)]. Using an open view-type infrared video pupillometer, pupil sizes were measured in subjects looking at targets 5 m or 1/3 m away under photopic(More)
PURPOSE To evaluate the effect of motion stimulation without changing binocular disparity on stereopsis in strabismic patients. METHODS Static and moving stereopsis were measured in 120 normal children and 30 strabismic patients (9 esotropia, 14 exotropia, 7 intermittent exotropia). Using a portable game device (PSP; SONY, Japan), we created stereoscopic(More)
The authors examined pupillary light reflexes to both red and blue stimuli using infrared video-pupillography in premature infants. Pupillary light reflexes were obtained in response to 470 nm blue and 635 nm red stimuli with varying intensities of 10 cd/m2 and 100 cd/m2. Red stimuli did not evoke a pupillary response in premature infants. However, blue(More)
Few studies report the prevalence and types of strabismus, or average of stereopsis in Japanese adults. We performed ophthalmological evaluation including motility and stereopsis during medical examinations at cooperative companies. We studies 1214 volunteers. The average age was 41.2 ± 12.6 (range 20–86) years. Examinations were carried out using their(More)
PURPOSE We investigated the effects of instillation of ripasudil hydrochloride hydrate (GLANATEC®) on pupil dynamics. MATERIALS AND METHODS Fourteen healthy participants (mean age: 30 years), who had no ophthalmic diseases other than refractive error, were enrolled in this study. A single dose of GLANATEC® was instilled into the left eye only. The(More)
Citation: Satou T, Goseki T, Asakawa K, Ishikawa H, Shimizu K. Effects of age and sex on values obtained by RAPDx pupillometer, and determined the standard values for detecting relative afferent pupillary defect. Trans Vis Sci Tech. 2016;5(2): 18, doi:10.1167/tvst.5.2.18 Purpose: To determine the effects of age and sex on the amplitude and latency scores(More)
We previously reported the standard values of the amplitude and latency scores in the RAPDx device for evaluating relative afferent pupillary defect (RAPD). Here, we evaluated RAPD in patients with optic nerve disease by using these standard values. Twenty-eight patients with current or previous optic nerve disease were enrolled in this study. Additionally,(More)