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Surface charge sensitivity of silicon nanowires: size dependence.
TLDR
It is found that nanowires of width >150 nm are virtually insensitive to the buffer pH, and computer simulations confirm this behavior and show that sensing can be extended even down to the single charge level. Expand
Imaging of HER2-expressing tumours using a synthetic Affibody molecule containing the 99mTc-chelating mercaptoacetyl-glycyl-glycyl-glycyl (MAG3) sequence
TLDR
Incorporation of a mercaptoacetyl-containing chelating sequence during chemical synthesis enabled site-specific 99mTc labelling of the ZHER2:342 Affibody molecule with preserved targeting capacity and showed specific tumour targeting in mice bearing LS174T xenografts. Expand
(99m)Tc-maEEE-Z(HER2:342), an Affibody molecule-based tracer for the detection of HER2 expression in malignant tumors.
TLDR
Increased hydrophilicity, combined with improved stability of the mercaptoacetyl-triglutamyl chelator, resulted in favorable biodistribution, making (99m)Tc-maEEE-Z(HER2:342) a promising tracer for clinical imaging of HER2 overexpression in tumors. Expand
99mTc-chelator engineering to improve tumour targeting properties of a HER2-specific Affibody molecule
TLDR
The introduction of serine residues in the chelator results in better tumour imaging properties of the Affibody molecule ZHER2:342 compared with glycyl-containing chelators and is favourable for imaging of tumours and metastases in the abdominal area. Expand
Affibody protein capture microarrays: synthesis and evaluation of random and directed immobilization of affibody molecules.
TLDR
The results from the biosensor analyses showed that directed immobilization strategies significantly improved the specific binding activity of affibody molecules, however, in the microarray system, random immobilization onto carboxymethyl dextran slides and oriented immobilization on thiol deXTran slides resulted in equally good signal intensities, whereas biotin-mediated immobilization upon streptavidin-coated slides produced slides with lower signal intensity and higher background staining. Expand
Pre-clinical evaluation of [111In]-benzyl-DOTA-Z(HER2:342), a potential agent for imaging of HER2 expression in malignant tumors.
TLDR
111In-benzyl-DOTA-Z(HER2:342) has a potential for imaging of HER2 expression in malignant tumors and the use of benzyl-DTPA provided higher tumor-to-blood and tumor- to-liver ratios. Expand
In vivo evaluation of cysteine-based chelators for attachment of 99mTc to tumor-targeting Affibody molecules.
TLDR
The results show that the use of a cysteine-based chelator enables 99mTc-labeling of Affibody molecules for imaging and indicates a new class of affinity proteins, which utilizes a scaffold based on a 58-amino acid domain derived from protein A. Expand
Chemical Synthesis of Triple‐Labelled Three‐Helix Bundle Binding Proteins for Specific Fluorescent Detection of Unlabelled Protein
TLDR
The synthetic, doubly fluorescent‐labelled affinity proteins were shown to function as fluorescent biosensors in an assay for the specific detection of unlabelled human IgG and IgA. Expand
Evaluation of Cysteine-Based Chelators for Attachment of 99 mTc to Tumor-Targeting Affibody Molecules
Division of Biomedical Radiation Sciences, Rudbeck Laboratory, Uppsala University, Sweden, School of Biotechnology, Division of Molecular Biotechnology, Royal Institute of Technology, Stockholm,Expand
Imaging of HER2-tumours with a site-specifically 99mTc-labelled Affibody containing a cysteinyldiglycyl chelator
TLDR
Imaging of HER2-tumours with a site-specifically 99mTc-labelled Affibody containing a cysteinyldiglycyl chelator shows clear improvement in the prognosis of these patients with central giant cell granuloma. Expand
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