Toru Nakahara

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Anti-HIV peptides with inhibitory activity against HIV-1 integrase (IN) have been found in overlapping peptide libraries derived from HIV-1 gene products. In a strand transfer assay using IN, inhibitory active peptides with certain sequential motifs related to Vpr- and Env-derived peptides were found. The addition of an octa-arginyl group to the inhibitory(More)
This study was conducted to evaluate the performance of Sugi lamina impregnated with low-molecular weight phenolic (LMWP) resin using the full cell process followed by curing at high temperature. In this study, penetration of LMWP resin into finger-jointed lamina was examined. Physical and mechanical properties, such as surface hardness, dimensional(More)
A synthetic antigen targeting membrane-fusion mechanism of HIV-1 has a newly designed template with C3-symmetric linkers mimicking N36 trimeric form. The antiserum produced by immunization of the N36 trimeric form antigen showed structural preference in binding to N36 trimer and stronger inhibitory activity against HIV-1 infection than the N36 monomer. Our(More)
Despite almost 30 years since the identification of the human immunodeficiency virus type I (HIV-1), development of effective AIDS vaccines has been hindered by the high mutability of HIV-1. The HIV-1 co-receptors CCR5 and CXCR4 are genetically stable, but viral proteins may mutate rapidly during the course of infection. CXCR4 is a seven transmembrane G(More)
In this article we shall give a survey of Hasse’s problem for integral power bases of algebraic number fields during the last half of century. Specifically, we developed this problem for the abelian number fields and we shall show several substantial examples for our main theorem [7] [9], which will indicate the actual method to generalize for the(More)
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