Toru Kusano

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Whether gastrectomy with D2 lymphadenectomy improves survival of patients with advanced gastric cancer (AGC) remains controversial. Few studies have described the pathological features of AGC with metastatic suprapancreatic lymph nodes (LN), which are the target of D2 lymphadenectomy. This study therefore aims to clarify the prognosis and clinical(More)
BACKGROUND AND AIM We have focused on sodium alginate (SA) solution as a potential submucosal injection material for endoscopic submucosal dissection (ESD). A previous SA solution had high viscosity and problems such as difficult handling. After its properties were adjusted, SA solution was examined in vitro and its clinical safety was evaluated. METHODS(More)
BACKGROUND Histones play important roles in both host defenses and inflammation related to microbial infection. A peptide mimotope (SSV) was identified from a novel histone H1 monoclonal antibody (16G9 mAb) that was shown to inhibit the mixed lymphocyte reaction. In the present study, an anti-SSV producing hybridoma was established. We investigated the(More)
Endoscopic surgery is one of minimally invasive medical treatments, which reduces both physical and mental burdens of a patient than conventional abdominal operations. At present, a variety of training environments for endoscopic surgery, such as a dry box, a virtual reality (VR) simulator, and an animal experiment have been prepared to cultivate certifying(More)
Secretory immunoglobulin A (s-IgA) plays an important role in both gut and systemic immunity. This study aimed to investigate the production of s-IgA resulting from a CO2 pneumoperitoneum compared with a laparotomy. Using enzyme-linked immunosorbent assays, s-IgA in stool, malondialdehyde (MDA), and Toll-like receptor 4 (TLR4) in the ileal tissue were(More)
OBJECTIVE Although pre-operative chemoradiation therapy for advanced lower rectal cancer is a controversial treatment modality, it is increasingly used in combination with surgery. Few studies have considered the combination of chemoradiation therapy followed by laparoscopic surgery for locally advanced lower rectal cancer; therefore, this study aimed to(More)
Background: There are few comprehensive studies on the prognosis of patients with suprapancreatic lymph node (LN) metastasis. In the present study, we evaluated prognostic factors in gastric cancer patients with suprapancreatic LN metastasis. Methods: Between June 1982 and February 2004, 62 patients with suprapancreatic LN metastasis underwent radical(More)
A 56-year-old man with advanced esophageal carcinoma and lymph node swelling of abdomen (cStage III) underwent neoadjuvant chemotherapy (NAC) with 5-FU/CDDP. The side effect was stomatitis of grade 2. Primary tumor and lymph node swelling revealed remarkable effectiveness after 2 courses of NAC. Esophageal carcinoma was not found by endoscopy. Reduction of(More)
Rare complication of free perforation in Crohn's disease was clinically reviewed on the basis of surgical experiences with Crohn's diseases. 1) Free perforation occurred in younger patients with steroid therapy. 2) There are no close correlation with the time duration of the disease affection. 3) The fortuitous locations of free perforation were the ileum(More)