Torsten Schön

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Phototransduction in retinal rods involves a G protein-coupled signaling cascade that leads to cGMP hydrolysis and the closure of cGMP-gated cation channels that are open in darkness, producing a membrane hyperpolarization as the light response. For many years there have also been reports of the presence of a phosphoinositide pathway in the rod outer(More)
The interphotoreceptor matrix (IPM), lying between retinal photoreceptor and pigment epithelial (RPE) cells, contains insulin-like growth factor I (IGF-I) immunoreactivity that co-elutes with authentic human IGF-I in HPLC analyses. Cultured human RPE cells synthesize and release IGF-I, raising the possibility that the RPE serves as a source of IPM IGF-I in(More)
PURPOSE To identify homeobox-containing genes that may play a role in the differentiation of ocular tissues. METHODS Total RNA was isolated from microdissected chicken embryo eye tissues at 3.5 days of development (embryonic day 3.5; E3.5). An "anchor-oligo-dT primer" was used for the synthesis of cDNA. Degenerate oligonucleotides designed from(More)
PURPOSE To determine the developmental expression and localization of mRNA for insulin-like growth factor binding protein-2 (IGFBP-2), a major binding protein of IGF-I and IGF-II, in ocular tissues of the embryonic and early posthatched chick. METHODS In situ hybridization and northern blot analysis were used to analyze the cellular origin and relative(More)
A novel structure learning algorithm for Bayesian Networks based on the Phyasrum Solver is introduced. First, the algorithm calculates pair wise correlation coefficients in the dataset. Within an initially fully connected Physarum-Maze, the length of the connections is given by the inverse correlation coefficient between the connected nodes. Then, the(More)
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