Torrance Jackson

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of glomerular filtration rate by renin-angiotensin system. Am.The role of the renin-angiotensin system (RAS) in autoregulating renal blood flow (RBF) and glomeru-lar filtration rate (GFR) during reductions in renal artery pressure (RAP) was examined in the following groups of anesthetized dogs after intrarenal infusion of AIIA, n, 10. In groups I and III,(More)
1,3-Butadiene (BD), a rodent carcinogen, is metabolized to mutagenic and DNA-reactive epoxides. In vitro data suggest that this oxidation is mediated by cytochrome P450 2E1 (CYP2E1). In this study, we tested the hypothesis that oxidation of BD by CYP2E1 is required for genotoxicity to occur. Inhalation exposures were conducted with B6C3F1 mice using a(More)
Genetic studies on spontaneous mouse mutants with hearing defects have provided important insights into the function of genes expressed in inner ear hair cells. Here we report on our genetic analyses of the deaf mutants varitint-waddler (Va) and jerker (Espnje). A high-resolution genetic map localizes VaJ to a 0.14 +/- 0.08 cM region between D3Mit85 and(More)
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