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Elevations of endogenous kynurenic acid produce spatial working memory deficits.

• Amy C Chess, Michael K Simoni, Torey E Alling, David J Bucci
• Schizophrenia bulletin
• 2007

Kynurenic acid (KYNA) is a tryptophan metabolite that is synthesized and released by astrocytes and acts as a competitive antagonist of the glycine site of N-methyl-D-aspartate receptors at high… (More)

Optimization and Evaluation of 5-Styryl-Oxathiazol-2-one Mycobacterium tuberculosis Proteasome Inhibitors as Potential Antitubercular Agents

• Francesco Russo, Johan Gising, +11 authors Mats Larhed
• ChemistryOpen
• 2015

This is the first report of 5-styryl-oxathiazol-2-ones as inhibitors of the Mycobacterium tuberculosis (Mtb) proteasome. As part of the study, the structure-activity relationship of oxathiazolones as… (More)

Antimycobacterial activity evaluation, time-kill kinetic and 3D-QSAR study of C-(3-aminomethyl-cyclohexyl)-methylamine derivatives.

• Deepak Kumar, K. Kranthi Raj, MaiAnn Bailey, Torey E Alling, Tanya Parish, Diwan Singh Rawat
• Bioorganic & medicinal chemistry letters
• 2013

A series of C-(3-aminomethyl-cyclohexyl)-methylamine derivatives were synthesized and evaluated for their antitubercular activity. Some of the compounds exhibited potent activity against… (More)

Advancement of Imidazo[1,2-a]pyridines with Improved Pharmacokinetics and Nanomolar Activity Against Mycobacterium tuberculosis.

• Garrett C Moraski, Lowell D Markley, +7 authors Marvin J Miller
• ACS medicinal chemistry letters
• 2013

A set of fourteen imidazo[1,2-a]pyridine-3-carboxamides was synthesized and screened against Mycobacterium tuberculosis H37Rv. The minimum inhibitory concentrations of twelve of these agents were ≤ 1… (More)

The 4-aminopiperidine series has limited anti-tubercular and anti-staphylococcus aureus activity

• N. Susantha Chandrasekera, Torey E Alling, +5 authors Tanya Parish
• Journal of Negative Results in BioMedicine
• 2015

Tuberculosis (TB) caused by Mycobacterium tuberculosis is the leading cause of death from a bacterial infection. The 4-aminopiperidine (PIP) series has been reported as having anti-bacterial activity… (More)

Synthesis and anti - tubercular activity of 3 - substituted benzo [ b ] thiophene - 1 , 1 -

• Susantha Chandrasekera, Mai Ann Bailey, +5 authors Tanya Parish
• 2017

Oxadiazoles Have Butyrate-Specific Conditional Activity against Mycobacterium tuberculosis.

• Julie V. Early, Allen Casey, +8 authors Tanya Parish
• Antimicrobial agents and chemotherapy
• 2016

Mycobacterium tuberculosis is a global pathogen of huge importance which can adapt to several host niche environments in which carbon source availability is likely to vary. We developed and ran a… (More)

Determination of compound kill kinetics against Mycobacterium tuberculosis.

• Julie Early, Torey E Alling
• Methods in molecular biology
• 2015

In this chapter, we describe how to determine the kill kinetics and minimum bactericidal concentration (MBC) of a compound against Mycobacterium tuberculosis. Techniques are described for three… (More)

A Dual Read-Out Assay to Evaluate the Potency of Compounds Active against Mycobacterium tuberculosis

• Juliane Ollinger, Mai Ann Bailey, +5 authors Tanya Parish
• PloS one
• 2013

Tuberculosis is a serious global health problem caused by the bacterium Mycobacterium tuberculosis. There is an urgent need for discovery and development of new treatments, but this can only be… (More)

Synthesis and evaluation of the 2,4-diaminoquinazoline series as anti-tubercular agents.

• Joshua O. Odingo, Theresa O'Malley, +13 authors Tanya Parish
• Bioorganic & medicinal chemistry
• 2014

The 2,4-diaminoquinazoline class of compounds has previously been identified as an effective inhibitor of Mycobacterium tuberculosis growth. We conducted an extensive evaluation of the series for its… (More)

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