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Endothelial microvascular networks affect gene-expression profiles and osteogenic potential of tissue-engineered constructs

• Torbjorn O. Pedersen, Anna L Blois, +8 authors Kamal Mustafa
• Stem Cell Research & Therapy
• 2012

A major determinant of the potential size of cell/scaffold constructs in tissue engineering is vascularization. The aims of this study were twofold: first to determine the in vitro angiogenic and… (More)

Release and bioactivity of bone morphogenetic protein-2 are affected by scaffold binding techniques in vitro and in vivo.

• Salwa Suliman, Zhe Xing, +11 authors Kamal Mustafa
• Journal of controlled release : official journal…
• 2015

A low dose of 1μg rhBMP-2 was immobilised by four different functionalising techniques on recently developed poly(l-lactide)-co-(ε-caprolactone) [(poly(LLA-co-CL)] scaffolds. It was either (i)… (More)

Biological effects of functionalizing copolymer scaffolds with nanodiamond particles.

• Zhe Xing, Torbjorn O. Pedersen, +8 authors Kamal Mustafa
• Tissue engineering. Part A
• 2013

Significant evidence has indicated that poly(L-lactide)-co-(ɛ-caprolactone) [(poly(LLA-co-CL)] scaffolds could be one of the suitable candidates for bone tissue engineering. Oxygen-terminated… (More)

In Vivo Host Response and Degradation of Copolymer Scaffolds Functionalized with Nanodiamonds and Bone Morphogenetic Protein 2.

• Salwa Suliman, Yang Sun, +8 authors Kamal Mustafa
• Advanced healthcare materials
• 2016

The aim is to evaluate the effect of modifying poly[(l-lactide)-co-(ε-caprolactone)] scaffolds (PLCL) with nanodiamonds (nDP) or with nDP+physisorbed BMP-2 (nDP+BMP-2) on in vivo host tissue response… (More)

Leukocyte transmigration into tissue-engineered constructs is influenced by endothelial cells through Toll-like receptor signaling

• Sushma Bartaula-Brevik, Torbjorn O. Pedersen, +5 authors Kamal Mustafa
• Stem Cell Research & Therapy
• 2014

Inflammation plays a crucial role in tissue regeneration, wound healing, and the success of tissue-engineered constructs. The aim of this study was to investigate the influence of human umbilical… (More)

Osteogenic stimulatory conditions enhance growth and maturation of endothelial cell microvascular networks in culture with mesenchymal stem cells

• Torbjorn O. Pedersen, Anna L Blois, +6 authors Kamal Mustafa
• Journal of tissue engineering
• 2012

To optimize culture conditions for in vitro prevascularization of tissue-engineered bone constructs, the development of organotypic blood vessels under osteogenic stimulatory conditions (OM) was… (More)

Cell seeding density is a critical determinant for copolymer scaffolds-induced bone regeneration.

• Mohammed Abdelmotaleb M. Yassin, Knut N Leknes, +5 authors Kamal Mustafa
• Journal of biomedical materials research. Part A
• 2015

Constructs intended for bone tissue engineering (TE) are influenced by the initial cell seeding density. Therefore, the objective of this study was to determine the effect of bone marrow stromal stem… (More)

Mesenchymal stem cells induce endothelial cell quiescence and promote capillary formation

• Torbjorn O. Pedersen, Anna L Blois, +7 authors Kamal Mustafa
• Stem Cell Research & Therapy
• 2013

Rapid establishment of functional blood vessels is a prerequisite for successful tissue engineering. During vascular development, endothelial cells (ECs) and perivascular cells assemble into a… (More)

Angiogenic and Immunomodulatory Properties of Endothelial and Mesenchymal Stem Cells

• Sushma Bartaula-Brevik, Torbjorn O. Pedersen, Anna Finne-Wistrand, Anne Isine Bolstad, Kamal Mustafa
• Tissue engineering. Part A
• 2016

It has been suggested that the effect of implanted cells on the local environment is important when selecting the appropriate cell type for tissue regeneration. Our aim was to compare the local… (More)

Hyperbaric oxygen stimulates vascularization and bone formation in rat calvarial defects.

• Torbjorn O. Pedersen, Z Xing, Anna Finne-Wistrand, Sølve Hellem, Khamis Mustafa
• International journal of oral and maxillofacial…
• 2013

Hyperbaric oxygen (HBO) therapy is used to treat or prevent tissue necrosis in patients undergoing irradiation. Many such patients require reconstructive surgery, but little is known of the effects… (More)

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