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  • Toran Sanli, Gregory R. Steinberg, Gurmit Singh, Theodoros Tsakiridis
  • Biology, Medicine
  • Cancer biology & therapy
  • 2014 (First Published: 1 February 2014)
  • AMP-activated protein kinase (AMPK), an established metabolic stress sensor, has gained popularity in cancer biology due to its ability to control cellular growth and mediate cell cycle checkpointsContinue Reading
  • Toran Sanli, Ayesha Rashid, +6 authors Theodoros Tsakiridis
  • Medicine
  • International journal of radiation oncology…
  • 2010 (First Published: 1 September 2010)
  • PURPOSE Adenosine monophosphate (AMP)-activated kinase (AMPK) is a molecular energy sensor regulated by the tumor suppressor LKB1. Starvation and growth factors activate AMPK through the DNA damageContinue Reading
  • Katja Linher-Melville, Stephanie Zantinge, Toran Sanli, Hertzel C. Gerstein, Theodoros Tsakiridis, Gurmit Singh
  • Biology, Medicine
  • BMC Cancer
  • 2010 (First Published: 1 December 2011)
  • BackgroundMammary carcinomas have been associated with a high-fat diet, and the rate of breast cancer in overweight post-menopausal women is up to 50% higher than in their normal-weight counterparts.Continue Reading
  • Toran Sanli, Caiqiong Liu, +7 authors Theodoros Tsakiridis
  • Biology, Medicine
  • Journal of thoracic oncology : official…
  • 2011 (First Published: 1 March 2011)
  • INTRODUCTION In this study, we investigated the effect of the 3-hydroxy-3-methylgutaryl-CoA reductase inhibitor lovastatin, as a sensitizer of lung cancer cells to ionizing radiation (IR). METHODSContinue Reading
  • Toran Sanli, Yaryna Storozhuk, +6 authors Theodoros Tsakiridis
  • Medicine
  • Radiotherapy and oncology : journal of the…
  • 2012 (First Published: 1 March 2012)
  • PURPOSE To analyze the (i) expression of AMPK in a variety of epithelial cancer cells, (ii) regulation of AMPK subunit expression by ionizing radiation (IR) and (iii) impact of AMPK on signalingContinue Reading