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- Eirik Fossgård, Tor Flå
- IEEE Transactions on Information Theory
- 2006

In this paper, we develop a code length principle which is invariant to the choice of parameterization on the model distributions, that is the code length remains the same under smooth transformations on the likelihood parameters. An invariant approximation formula for easy computation of the marginal distribution is provided for Gaussian likelihood models.… (More)

- Steinar Thorvaldsen, Elinor Ytterstad, Tor Flå
- APBC
- 2006

Multiple sequence alignments can provide information for comparative analyses of proteins and protein populations. We present some statistical trend-tests that can be used when an aligned data set can be divided into two or more populations based on phenotypic traits such as preference of temperature, pH, salt concentration or pressure. The approach is… (More)

- Steinar Thorvaldsen, Tor Flå, Nils Willassen
- BMC Bioinformatics
- 2010

Statistical bioinformatics is the study of biological data sets obtained by new micro-technologies by means of proper statistical methods. For a better understanding of environmental adaptations of proteins, orthologous sequences from different habitats may be explored and compared. The main goal of the DeltaProt Toolbox is to provide users with important… (More)

- Stig Rune Jensen, Tor Flå, Dan Jonsson, Rune Sørland Monstad, Kenneth Ruud, Luca Frediani
- Physical chemistry chemical physics : PCCP
- 2016

Multiwavelets are emerging as an attractive alternative to traditional basis sets such as Gaussian-type orbitals and plane waves. One of their distinctive properties is the ability to reach the basis set limit (often a chimera for traditional approaches) reliably and consistently by fixing the desired precision ε. We present our multiwavelet implementation… (More)

- Arturo Tozzi, Tor Flå, James F Peters
- Journal of neuroscience research
- 2016

The minimum frustration principle (MFP) is a computational approach stating that, over the long time scales of evolution, proteins' free energy decreases more than expected by thermodynamical constraints as their amino acids assume conformations progressively closer to the lowest energetic state. This Review shows that this general principle, borrowed from… (More)

- Tor Flå
- 2001

We parameterize the phase space density by time dependent diffeomorphic, Poisson preserving transformations on phase space acting on a reference density solution. We can look at these as transformations which fix time on the extended space of phase space and time. In this formulation the Vlasov equation is replaced by a constraint equation for the above… (More)

- Steinar Thorvaldsen, Tor Flå, Nils Willassen
- ISBMDA
- 2005

The use of sequence alignments for establishing protein homology relationships has an extensive tradition in the field of bioinformatics, and there is an increasing desire for more statistical methods in the data analysis. We present statistical methods and algorithms that are useful when the protein alignments can be divided into two populations based on… (More)

- Said Hassan Ahmed, Tor Flå
- PRIB
- 2009

- Clemens Woywod, Franz X. Gruber, Richard A. Engh, Tor Flå
- PloS one
- 2017

Targeted inhibition of the oncogenic BCR-ABL1 fusion protein using the ABL1 tyrosine kinase inhibitor imatinib has become standard therapy for chronic myelogenous leukemia (CML), with most patients reaching total and durable remission. However, a significant fraction of patients develop resistance, commonly due to mutated ABL1 kinase domains. This motivated… (More)

- Steinar Thorvaldsen, Elinor Ytterstad, Tor Flå
- ISBRA
- 2007