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The purpose of in vivo–in vitro correlation (IVIVC) modeling is described. These models are usually fitted to deconvoluted data rather than the raw plasma drug concentration/time data. Such a two-stage analysis is undesirable because the deconvolution step is unstable and because the fitted model predicts the fraction of a dosage unit dissolved/absorbed in(More)
A major goal of the pharmaceutical scientist is finding a relationship between an in vitro characteristic of an oral dosage form and its in vivo performance. One such relationship between drug dissolution (or absorption) in vivo and that in vitro is known as an 'in vitro-in vivo correlation' (IVIVC) whose importance stems from the fact that it may be used(More)
Some new nonlinear models for the relationship between the fraction of drug dose dissolved (absorbed) in vivo and that dissolved in vitro are described. The models are empirical in nature and are generalizations of the linear model that, at present, is the most commonly used model. The modeling approach is based on considering the time at which a drug(More)
This paper reviews the work carried out in the field of reconfigurable antennas, and in specific the reconfigurable MEMS (Micro-Electro-Mechanical Systems) antennas. The application of MEMS to antennas is studied and compared with the various implementations such as pattern reconfigurable MEMS antennas, mechanically actuated MEMS antennas, capacitive MEMS(More)
Recent studies have suggested that certain nanomaterials can interfere with optically based cytotoxicity assays resulting in underestimations of nanomaterial toxicity. As a result there has been growing interest in the use of whole cell electrochemical biosensors for nanotoxicity applications. Herein we report application of an electrochemical cytotoxicity(More)
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