Tony Mets

8Rose Njemini
7Ellen Gorus
4Margareta Lambert
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This study evaluated whether reaction times (RT) and performance variability are potential markers for the early detection of Alzheimer's disease (AD). Cognitively healthy elderly (n = 218), persons with amnestic MCI (a-MCI) (n = 29) and patients with AD (n = 50) were examined with RT tasks with increasing complexity, subdividing RT into a decision and a(More)
BACKGROUND Low grip strength is recognized as one of the characteristics of frailty, as are systemic inflammation and the sensation of fatigue. Contrary to maximal grip strength, the physical resistance of the muscles to fatigue is not often included in the clinical evaluation of elderly patients. The aim of this study was to investigate if the grip(More)
PURPOSE To investigate the reliability of a 3D-accelerometry based gait analysis, and its correlates with clinical status and fall-risk. METHODS Forty elderly subjects presenting with increased fall-risk (OFR), 41 elderly controls (OC) and 40 young controls (aged 80.6±5.4, 79.1±4.9 and 21.6±1.4 years respectively) underwent three gait evaluations (two(More)
BACKGROUND Heat shock proteins (Hsp) are ubiquitously synthesised in virtually all species and it is hypothesised that they might have beneficial health effects. Recent studies have identified circulating Hsp as an important mediator in inflammation - the effects of low-grade inflammation in the aging process are overwhelming. While much is known about(More)
BACKGROUND AND AIMS Performance variability of reaction time is regarded as an important parameter for cognitive functioning with aging. We investigated three types of variability, diversity (or variability between persons), dispersion (variability across trials within one task) and inconsistency (variability across testing occasions), while distinguishing(More)
BACKGROUND There is growing evidence for the significant involvement of inflammatory processes in the development of muscle wasting in old age. Therefore, any disease accompanied by inflammation can be threatening to the muscle function in geriatric patients. METHODS Sixty-three hospitalized geriatric patients (42 female, 21 male; mean age 84.2 +/- 5.7(More)
BACKGROUND The 6 minutes walk test (6MWT) is a useful assessment instrument for the exercise capacity of elderly persons. The impact of the health status on the 6MWT-distance in elderly, however, remains unclear, reducing its value in clinical settings. The objective of this study was to investigate to what extent the 6MWT-distance in community dwelling(More)
The purpose of the study was to examine the acute effect of a strength training session on brain-derived neurotrophic factor and insulin-like growth factor 1. Furthermore, the influence of a 10-week strength training program on brain-derived neurotrophic factor (BDNF) and insulin-like growth factor-1 (IGF-1) resting levels and memory performance was(More)
INTRODUCTION Given the safety issues of non-steroidal anti-inflammatory drugs (NSAID) and the robustness of guidelines, making treatment choices in daily clinical practice is increasingly difficult. This study aimed systematically to analyse the opinions of a multidisciplinary European expert panel on the appropriateness of different NSAID, with or without(More)
PURPOSE To examine the influence of a selective noradrenaline reuptake inhibitor (SNRI) on the exercise-induced increase in circulating brain-derived neurotrophic factor (BDNF). METHODS In a double-blind, placebo-controlled, crossover design, 11 young, healthy male subjects were treated with either placebo or reboxetine. On each occasion, they performed a(More)