Tony Malmqvist

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The sphingomyelinase (beta-hemolysin) production by 180 Staphylococcus aureus strains was determined in a qualitative enzyme impression test (EIT) and all but 4 strains in a quantitative enzyme assay test (EAT) using 14C-sphingomyelin as test substrates. A total of 59 strains (33%) were positive for enzyme production in the EIT. The highest frequency was(More)
The retinoic acid receptor (RAR) α system plays a key role in the adult brain, participating in the homeostatic control of synaptic plasticity, essential for memory function. Here we show that RARα signalling is down-regulated by amyloid beta (Aβ), which inhibits the synthesis of the endogenous ligand, retinoic acid (RA). This results in the counteraction(More)
The microtubule-associated protein tau is predominantly localized in the axonal compartment over the entire length of the axon in neurons. The mechanisms responsible for the localization of tau in axons at long distance from the cell body are not properly understood. Using fluorescence in situ hybridization, we show that tau mRNA is present in the central(More)
An assay system for phospholipases C has been described with sphingomyelin immobilized to octyl-Sepharose CL-4B as substrate. The immobilization procedure was further developed and used with [14 C-choline]-sphingomyelin and [14C-choline] phosphatidylcholine (lecithin). These immobilized radioactive phospholipids made the enzymatic assays easier to perform(More)
  • Tony Malmqvist
  • Acta pathologica, microbiologica, et immunologica…
  • 1983
Bacterial hydrophobicity was measured as the affinity of palmitic acid to the cell surface. Cell surface and buffer were regarded as two immiscible phases with different affinity for the fatty acid. After equilibration of the system, the partition quotient (PQ) between the two phases was calculated. The bacteria hydrophobicity was expressed as the amount of(More)
Stimulation of retinoic acid (RA) mediated signalling pathways following neural injury leads to regeneration in the adult nervous system and numerous studies have shown that the specific activation of the retinoic acid receptor β (RARβ) is required for this process. Here we identify a novel mechanism by which neuronal RARβ activation results in the(More)
Chronic infection by high risk human papillomavirus (HPV) strains may lead to cancer. Expression of the two viral oncoproteins E6 and E7 is largely responsible for immortalization of infected cells. The HPV E6 is a small (approximately 150 residues) two domain protein that interacts with a number of cellular proteins including the ubiquitin ligase(More)
Eucaryotic cell surface hydrophobicity was measured as a partition of palmitic acid between the cell surface and the surrounding buffer. The method was found to be independent of cell mass or amount of palmitic acid within a large interval. An estimation of cell stability could also be obtained. The effects of Ca and Mg ions on cell hydrophobicity and(More)
UNLABELLED Failure of axonal regeneration in the central nervous system (CNS) is mainly attributed to a lack of intrinsic neuronal growth programs and an inhibitory environment from a glial scar. Phosphatase and tensin homolog (PTEN) is a major negative regulator of neuronal regeneration and, as such, inhibiting its activity has been considered a(More)