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The tyrosine kinase inhibitor herbimycin A was found to block NF-kappa B stimulation in response to interleukin-1 and phorbol 12-myristate 13-acetate in EL4.NOB-1 thymoma cells and phorbol 12-myristate 13-acetate in Jurkat T lymphoma cells. The effect appeared not to involve inhibition of tyrosine kinase activation as neither interleukin-1 nor phorbol(More)
Nuclear factor kappa B (NFKB) is a transcription factor that is activated in many different cell types. In response to viruses, bacteria and stress factors as well as phorbol esters and inflammatory cytokines such as interleukin 1 ( ILl ) , NFKB becomes activated [ I ] . It regulates the expression of various genes involved in the immune and inflammatory(More)
The effect of in-vivo administration of N-2-hydroxyethylpiperazine-N'-2- ethane sulphonic acid (HEPES) and taurine on rat paw oedema and reactive oxidant production was examined. Carrageenan-induced paw oedema was attenuated following intraperitoneal injection of HEPES. Chemiluminescence production by isolated peripheral blood mononuclear cells (PBMC) was(More)
Protein kinase C (PKC) has been implicated in interleukin 1 (IL1) signal transduction in a number of cellular systems, either as a key event in IL1 action or as a negative regulator. Here we have examined the effects of two PKC inhibitors, staurosporine and the more selective agent Ro 31-8220, on IL1 responses in the murine thymoma line EL4.NOB-1. A 1 h(More)
A Bachelor of Engineering in Precision Engineering programme at Limerick Institute of Technology (LIT) has been created in a collaborative response to the needs of the industry. This new one year duration add-on programme was developed and implemented in an eight month period. The programme differs from the norm in the nature of its development, the(More)
As part of the initial assessment of the geothermal power potential of Indonesia an electronic model, (IGSEP), Mahon, (1987), was developed to prioritise the most favourable resources and determine the least cost development scenarios for generating geothermal electricity. The model was tested and assessed using data from 100 different geothermal prospects(More)
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