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A variety of new algorithms has begun to enable model checking of industrial-sized netlists. This work attempts to apply that technology to the verification of embedded software: C programs that manipulate integers and contain unstructured control flow, but are not recursive and do not dynamically allocate memory. We describe a synthesis procedure for… (More)
BACKGROUND Cardiac tamponade is a condition whereby fluid accumulation in the pericardial sac surrounding the heart causes elevation and equilibration of pericardial and cardiac chamber pressures, reduced cardiac output, changes in hemodynamics, partial chamber collapse, pulsus paradoxus, and arterio-venous acid-base disparity. Our large-scale model of the… (More)
BACKGROUND Mathematical modeling can be employed to overcome the practical difficulty of isolating the mechanisms responsible for clinical heart failure in the setting of normal left ventricular ejection fraction (HFNEF). In a human cardiovascular respiratory system (H-CRS) model we introduce three cases of left ventricular diastolic dysfunction (LVDD): (1)… (More)
Perampanel is a selective, noncompetitive AMPA receptor antagonist with demonstrated efficacy and tolerability in partial seizures in patients aged ≥ 12 years in Phase III studies. Post-hoc analysis of these studies was conducted to determine the efficacy and tolerability of perampanel based on the number of concomitant antiepileptic drugs (AEDs) at… (More)
Electronic system-level (ESL) design automation has been identified by Dataquest as the next productivity boost for the semiconductor industry. We have put together a distinguished panel of experts to discuss if we are ready for system-level synthesis.