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Alterations to blood-brain barrier (BBB) adhesion molecules and junctional integrity during neuroinflammation can promote central nervous system (CNS) pathology. The chemokine CCL2 is elevated during CNS inflammation and is associated with endothelial dysfunction. The effects of CCL2 on endothelial adherens junctions (AJs) have not been defined. We(More)
HIV infection and HIV neurocognitive impairment are major global health problems. The prevalence of HIV associated neurocognitive disorders (HAND) is increasing as people with HIV are living longer due to the success of antiretroviral therapies. Our laboratory identified the soluble form of (sPrPc), the cellular non-pathogenic isoform of the prion protein,(More)
I arrived home from work to find my husband uncharacteristically sitting at the dining room table, waiting for me to walk through the door. He said, " Sweetheart, I think there is something wrong with me. " My heart dropped as I noticed the left-sided Horner syndrome that had developed overnight and as I watched his face turn bright red when he lifted his(More)
BACKGROUND Epstein-Barr virus-positive mucocutaneous ulcer (EBVMCU) is a recently recognized B cell lymphoproliferative disorder that is driven by latent EBV infection and causes discrete ulcerations in the oropharynx, gastrointestinal tract, and skin. Local attenuation of immunosurveillance associated with iatrogenic immunosuppressant use, primary(More)
A South African girl with CANDLE Syndrome is reported with emphasis on the orodental features and dental management. Clinical manifestations included short stature, wasting of the soft tissue of the arms and legs, erythematous skin eruptions and a prominent abdomen due to hepatosplenomegaly. Generalized microdontia, confirmed by tooth measurement and(More)
Muramyl peptides (MPs) are bacterially derived sleep factors which stimulate slow wave sleep. In the neonate, MPs are capable of inducing quiet sleep and suppressing active sleep. Given that active sleep is thought to be important for brain development during this period, the possibility that changes in the availability of MPs in the neonate may affect(More)
This article examines the experience of families who contacted a child and family community mental health treatment center, but then did not follow through to receive even one session of diagnosis or treatment at the agency. The paper reports the base rate for this behavior in a large (N = 2,358) sample of cases who either only made inquiry or who received(More)
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