• Publications
  • Influence
Cryptosporidium parvum Infection of Human Intestinal Xenografts in SCID Mice Induces Production of Human Tumor Necrosis Factor Alpha and Interleukin-8
TLDR
It is demonstrated that human intestinal cells produce proinflammatory cytokines in response to C. parvum-induced diarrhea, and this work establishes SCID-HU-INT mice as a model system to study the interactions of C.parvum with the human intestine. Expand
Adoptive Transfer of In Vitro-Stimulated CD4+CD25+ Regulatory T Cells Increases Bacterial Clearance and Improves Survival in Polymicrobial Sepsis
TLDR
Adoptive transfer of in vitro-stimulated Tregs in both prevention and therapeutic modes significantly improved survival of cecal ligation and puncture mice and suggest a novel role for T Regs in sepsis. Expand
FGF21 is increased by inflammatory stimuli and protects leptin-deficient ob/ob mice from the toxicity of sepsis.
TLDR
FGF21 is a positive APR protein that protects animals from the toxic effects of LPS and sepsis, and treatment with exogenous FGF21 reduced the number of animals that die and the rapidity of death after LPS administration in leptin-deficient ob/ob mice and to a lesser extent in control mice. Expand
Protection against Invasive Amebiasis by a Single Monoclonal Antibody Directed against a Lipophosphoglycan Antigen Localized on the Surface of Entamoeba histolytica
A panel of monoclonal antibodies was raised from mice immunized with a membrane preparation from Entamoeba histolytica, the pathogenic species causing invasive amebiasis in humans. Antibody EH5 gaveExpand
Evaluation of protein C and other biomarkers as predictors of mortality in a rat cecal ligation and puncture model of sepsis*
TLDR
The data from this study indicate that an early decrease in protein C concentration predicts poor outcome in a rat sepsis model and indicates that increases in the CXC chemokines macrophage inflammatory protein-2 and KC precede poor outcome. Expand
Identification of an Epitope on the Entamoeba histolytica 170-kD Lectin Conferring Antibody-mediated Protection against Invasive Amebiasis
TLDR
Rec recombinant proteins corresponding to four distinct domains of the molecule, and synthetic peptides are used to localize both protective and exacerbative epitopes of the heavy chain subunit of the lectin, showing that protective immunity after vaccination can be correlated with the development of an antibody response to a region of 25 amino acid residues of the Lectin. Expand
Cecal ligation and puncture with total parenteral nutrition: a clinically relevant model of the metabolic, hormonal, and inflammatory dysfunction associated with critical illness.
TLDR
The results indicate that addition of TPN to CLP provides a clinically relevant animal model of critical illness with associated hyperglycemia that may provide utility for the testing of glucoregulatory and other therapeutic modalities. Expand
Enhanced B Cell Expansion, Survival, and Humoral Responses by Targeting Death Receptor 6
TLDR
This is the first demonstration of a regulatory role of DR6 in the activation and function of B cells in the presence of T-dependent as well as T-independent type I and II antigens. Expand
Effects of hyperglycemia and insulin therapy on outcome in a hyperglycemic septic model of critical illness.
TLDR
Hyperglycemia is associated with greater morbidity and mortality in sepsis and Insulin therapy significantly improved survival suggesting that management of hyper glycemia with insulin may improve outcome in septic patients. Expand
Accelerated Onset and Increased Severity of Acute Graft-Versus-Host Disease Following Adoptive Transfer of DR6-Deficient T Cells
TLDR
These findings support the hypothesis that DR6 serves as an important regulatory molecule in T cell immune responses and the identification and use of DR6 ligands and/or agonistic Abs to DR6 may represent useful therapeutics in the treatment of T cell-mediated diseases such as GVHD. Expand
...
1
2
...