Tongfei A. Wang

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Daily rhythms of mammalian physiology, metabolism, and behavior parallel the day-night cycle. They are orchestrated by a central circadian clock in the brain, the suprachiasmatic nucleus (SCN). Transcription of clock genes is sensitive to metabolic changes in reduction and oxidation (redox); however, circadian cycles in protein oxidation have been reported(More)
Thalamocortical neurons in dorsal lateral geniculate nucleus (dLGN) dynamically convey visual information from retina to the neocortex. Activation of metabotropic glutamate receptors (mGluRs) exerts multiple effects on neural integration in dLGN; however, their direct influence on the primary sensory input, namely retinogeniculate afferents, is unknown. In(More)
Brain plasticity, the ability of the nervous system to encode experience, is a modulatory process leading to long-lasting structural and functional changes. Salient experiences induce plastic changes in neurons of the hippocampus, the basis of memory formation and recall. In the suprachiasmatic nucleus (SCN), the central circadian (~24-h) clock, experience(More)
a Beckman Institute for Advanced Science and Technology, b Department of Pharmacology 6 c Department of Molecular & Integrative Physiology, d Cell and Developmental Biology, 7 e Neuroscience Program 8 University of Illinois, Urbana, IL 61801 9 10 Running Head: Modulation of pallido-thalamic GABAergic transmission 11 12
Febrile seizures represent a serious adverse event following measles, mumps and rubella (MMR) vaccination. We conducted a series of genome-wide association scans comparing children with MMR-related febrile seizures, children with febrile seizures unrelated to vaccination and controls with no history of febrile seizures. Two loci were distinctly associated(More)
Over 20% of the drugs for treating human diseases target ion channels, but no cancer drug approved by the US Food and Drug Administration (FDA) is intended to target an ion channel. We found that the EAG2 (Ether-a-go-go 2) potassium channel has an evolutionarily conserved function for promoting brain tumor growth and metastasis, delineate downstream(More)
Govindaiah G, Wang T, Gillette MU, Crandall SR, Cox CL. Regulation of inhibitory synapses by presynaptic D4 dopamine receptors in thalamus. J Neurophysiol 104: 2757–2765, 2010. First published September 8, 2010; doi:10.1152/jn.00361.2010. Dopamine (DA) receptors are the principal targets of drugs used in the treatment of schizophrenia. Among the five DA(More)
SIGNIFICANCE Functional states of organisms vary rhythmically with a period of about a day (i.e., circadian). This endogenous dynamic is shaped by day-night alternations in light and energy. Mammalian circadian rhythms are orchestrated by the hypothalamic suprachiasmatic nucleus (SCN), a brain region specialized for timekeeping. These autonomous ~24-h(More)
Recent discoveries suggest that the initiation of eukaryotic DNA replication involves at least two steps--one occurring near the completion of mitosis and the other at the onset of S phase--that bring about the ordered assembly of initiator proteins at the origin. The identification and characterization of components involved in promoting or antagonizing(More)
Dopamine (DA) receptors are the principal targets of drugs used in the treatment of schizophrenia. Among the five DA receptor subtypes, the D(4) subtype is of particular interest because of the relatively high affinity of the atypical neuropleptic clozapine for D(4) compared with D(2) receptors. GABA-containing neurons in the thalamic reticular nucleus(More)
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