Tong Zhang

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Silencing specificity is a critical issue in the therapeutic applications of siRNA, particularly in the treatment of single nucleotide polymorphism (SNP) diseases where discrimination against single nucleotide variation is demanded. However, no generally applicable guidelines are available for the design of such allele-specific siRNAs. In this paper, the(More)
In the title compound,4H 2 O, the Ce 3+ ion is nine-coordinated by two O atoms and two N atoms from one single and from one double deprotonated pyridine-2,5-dicarboxylate ligand and five water molecules in a distorted monocapped square-antiprismatic geometry. In the crystal, extensive O—HÁ Á ÁO hydrogen-bonding interactions result in a three-dimensional(More)
In the title hydrated molecular salt, C(2)H(10)N(2) (2+)·2C(8)H(9)N(2)O(4) (-)·H(2)O, an intra-molecular O-H⋯O hydrogen bond occurs in the anion, forming an S(7) ring. The -CO(2) and -CO(2)H groups make dihedral angles of 3.2 (2) and 2.0 (3)°, respectively, with the five-membered ring. In the crystal, N-H⋯O, N-H⋯N and O-H⋯O hydrogen bonds lead to the(More)
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