Tong Zhang

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Fibroblast growth factor 21 (FGF21) is a hormone secreted predominantly in the liver, pancreas and adipose tissue. Recently, it has been reported that FGF21-Transgenic mice can extend their lifespan compared with wild type counterparts. Thus, we hypothesize that FGF21 may play some roles in aging of organisms. In this study d-galactose (d-gal)-induced aging(More)
The response of cardiomyocytes to biomechanical stress can determine the pathophysiology of hypertrophic cardiac disease, and targeting the pathways regulating these responses is a therapeutic goal. However, little is known about how biomechanical stress is sensed by the cardiomyocyte sarcomere to transduce intracellular hypertrophic signals or how the(More)
FGF21 is recently discovered with pleiotropic effects on glucose and lipid metabolism. However, the potential protective effect of FGF21 against d-gal-induced injury in the liver has not been demonstrated. The aim of this study is to investigate the pathophysiological role of FGF21 on hepatic oxidative injury and apoptosis in mice induced by d-gal. The(More)
Our objective is to determine if a first-price auction or a posted-price market provides a seller with the larger expected revenue when buyers have a common value for the item being sold. An agent-based, posted-price market and an agent-based, first-price common-value auction with a reserve price are developed to compare these selling methods. When the(More)
The Publisher and Editor retract this article in accordance with the recommendations of the Committee on Publica tion Ethics (COPE). After a thorough investigation we have strong reason to believe that the peer review process was compromised.
Silencing specificity is a critical issue in the therapeutic applications of siRNA, particularly in the treatment of single nucleotide polymorphism (SNP) diseases where discrimination against single nucleotide variation is demanded. However, no generally applicable guidelines are available for the design of such allele-specific siRNAs. In this paper, the(More)
Acute activation of calcium/calmodulin-dependent protein kinase (CaMKII) in permeabilized phospholamban knockout (PLN-KO) mouse myocytes phosphorylates ryanodine receptors (RyRs) and activates spontaneous local sarcoplasmic reticulum (SR) Ca release events (Ca sparks) even at constant SR Ca load. To assess how CaMKII regulates SR Ca release in intact(More)
The GIS web portal usually functions as a web-based gateway to integrated and distributed geographic resources. Although current GIS web portals are gaining popularity among GIS users and are of great significance for building distributed Internet GIS, they remain weak in terms of analytical and modeling components. We discuss the possibilities of(More)