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Mutations at the mouse Fused locus have pleiotropic developmental effects, including the formation of axial duplications in homozygous embryos. The product of the Fused locus, Axin, displays similarities to RGS (Regulators of G-Protein Signaling) and Dishevelled proteins. Mutant Fused alleles that cause axial duplications disrupt the major mRNA, suggesting(More)
This paper describes automatic speech recognition systems that satisfy two technological objectives. First, we seek to improve the automatic labeling of prosody, in order to aid future research in automatic speech understanding. Second, we seek to apply statistical speech recognition models of prosody for the purpose of reducing the word error rate of an(More)
Fibroblast growth factor 21 (FGF21) is a hormone secreted predominantly in the liver, pancreas and adipose tissue. Recently, it has been reported that FGF21-Transgenic mice can extend their lifespan compared with wild type counterparts. Thus, we hypothesize that FGF21 may play some roles in aging of organisms. In this study d-galactose (d-gal)-induced aging(More)
FGF21 is recently discovered with pleiotropic effects on glucose and lipid metabolism. However, the potential protective effect of FGF21 against d-gal-induced injury in the liver has not been demonstrated. The aim of this study is to investigate the pathophysiological role of FGF21 on hepatic oxidative injury and apoptosis in mice induced by d-gal. The(More)
Perhaps the most fundamental application of affective computing will be Human-Computer Interaction (HCI) in which the computer should have the ability to detect and track the user's affective states, and make corresponding feedback. The human multi-sensor affect system defines the expectation of multimodal affect analyzer. In this paper, we present our(More)
Advances in computer processing power and emerging algorithms are allowing new ways of envisioning Human Computer Interaction. This paper focuses on the development of a computing algorithm that uses audio and visual sensors to detect and track a user's affective state to aid computer decision making. Using our Multi-stream Fused Hidden Markov Model(More)
The Publisher and Editor retract this article in accordance with the recommendations of the Committee on Publica tion Ethics (COPE). After a thorough investigation we have strong reason to believe that the peer review process was compromised.
To explore the global mechanisms of estrogen-regulated transcription, we used chromatin immunoprecipitation coupled with DNA microarrays to determine the localization of RNA polymerase II (Pol II), estrogen receptor alpha (ERalpha), steroid receptor coactivator proteins (SRC), and acetylated histones H3/H4 (AcH) at estrogen-regulated promoters in MCF-7(More)
This paper presents an approach to automatically recognize emotion which children exhibit in an intelligent tutoring system. Emotion recognition can assist the computer agent to adapt its tutorial strategies to improve the efficiency of knowledge transmission. In this study, we detect three emotional classes: confidence, puzzle, and hesitation. Emotion is(More)
This paper computationalizes two linguistic concepts, contrast and focus, for the extraction of pragmatic and semantic salience from spontaneous speech. Contrast and focus have been widely investigated in modern linguistics, as categories that link intonation and information/discourse structure. This paper demonstrates the automatic tagging of contrast and(More)