Tong-Cun Zhang

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In response to stress signals, postnatal cardiomyocytes undergo hypertrophic growth accompanied by activation of a fetal gene program, assembly of sarcomeres, and cellular enlargement. We show that hypertrophic signals stimulate the expression and transcriptional activity of myocardin, a cardiac and smooth muscle-specific coactivator of serum response(More)
Telomeres are critical in maintaining chromosome and genomic stability. Arsenic, a human carcinogen as well as an anticancer agent, is known for its clastogenicity. To better understand molecular mechanisms of arsenic actions, we investigated arsenite effects on telomere and telomerase and determined cell growth and apoptosis in HL-60 and HaCaT cells in(More)
Genes coding for bile salt hydrolase of Lactobacillus plantarum CGMCC 8198, a novel probiotic strain isolated from silage, were identified, analyzed and cloned. L. plantarum strongly resisted the inhibitory effects of bile salts and also decreased serum cholesterol levels by 20 % in mice with hypercholesterolemia. Using RT-PCR analysis, bsh2, bsh3 and bsh4(More)
We report the complete genome sequence of Lactobacillus plantarum CGMCC 8198, a novel probiotic strain isolated from fermented herbage. We have determined the complete genome sequence of strain L. plantarum CGMCC 8198, which consists of genes that are likely to be involved in dairy fermentation and that have probiotic qualities.
Mesenchymal stem cells (MSCs) are known to undergo endothelial differentiation in response to treatment with vascular endothelial growth factor (VEGF), but their angiogenic ability is poorly characterized. In the present study, we aimed to further investigate the role of Rho/MRTF-A in angiogenesis by MSCs and the effect of the Rho/MRTF-A pathway on the(More)
Myocardin is a potent coactivator of SRF and expressed mainly in cardiomyocytes and smooth muscle cells (SMCs), Myocardin is important for SMC differentiation, but its precise role in regulating the initiation of SMC development is less clear. Constuction and function analysis of myocardin promoter luciferase reporter plasmid will provide the theory basis(More)
Bacillus subtilis (B. subtilis) is a kind of Gram positive bacteria possessing multiple enzyme systems, which might be useful in wastewater treatment. In this paper, in order to confirm whether Bacillus subtilis BS7.29, a novel strain isolated from soil in our previous work, could be applied in the wastewater treatment, its effects on assimilation of(More)
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