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- Tsutomu Omatsu, Meng Ling Moi, +9 authors Ichiro Kurane
- The Journal of general virology
- 2011
Dengue virus (DENV) causes a wide range of illnesses in humans: dengue fever (DF), dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). Animal models that constantly develop high levels of… (More)
- Tomoyuki Yoshida, Tsutomu Omatsu, +10 authors Hirofumi Akari
- Archives of Virology
- 2011
CD16 is a major molecule expressed on NK cells. To directly assess the role of natural killer (NK) cells in dengue virus (DENV) infection in vivo, CD16 antibody-treated tamarins were inoculated with… (More)
- Akatsuki Saito, Masako Nomaguchi, +11 authors Hirofumi Akari
- Microbes and infection
- 2011
Human immunodeficiency virus type 1 (HIV-1) hardly replicates in Old World monkeys. Recently, a mutant HIV-1 clone, NL-DT5R, in which a small part of gag and the entire vif gene are replaced with… (More)
- Ikuo Tomioka, Eiji Mizutani, +4 authors Eimei Sato
- The Journal of reproduction and development
- 2007
The present study was conducted to demonstrate the spindle formation and behavior of chromosomes and microtubules during first division in reconstructed rat embryos produced by somatic cell nuclear… (More)
- Kiyoshi Aita, Hiroshi Irie, A. Hajime Koyama, Akio Fukuda, Tomoyuki Yoshida, Junji Shiga
- Archives of Virology
- 2001
 Replication of herpes simplex virus type 1 (HSV-1) in the adrenal gland of mice was observed 12 h after intravenous inoculation, peaked at 48 h (7 × 107 PFU/tissue), and was maintained until death.… (More)
- Akatsuki Saito, Yoshi Kawamoto, +7 authors Hirofumi Akari
- Front. Microbio.
- 2012
A recent study showed that the frequency of an antiretroviral factor TRIM5 gene-derived isoform, TRIMCyp, in cynomolgus macaques (Macaca fascicularis) varies widely according to the particular… (More)
- K. Noma, Katsuhiro Kiyotani, +4 authors Tomoyuki Yoshida
- Archives of Virology
- 1998
Multi-cycle replication and plaque formation of influenza A and B viruses and cleavage activation of their hemagglutinin (HA) by an endogenous protease(s) were examined in two MDCK cell lines,… (More)
- Yuki Iwasaki, Ken-ichi Mori, +16 authors Hirofumi Akari
- Front. Microbio.
- 2011
It has been shown that infection of GB virus B (GBV-B), which is closely related to hepatitis C virus, develops acute self-resolving hepatitis in tamarins. In this study we sought to examine… (More)
- Takahiro Toda, Kanna Ohi, +4 authors Kiyoshi Sugiyama
- Drug metabolism and pharmacokinetics
- 2009
Ciprofloxacin (CPX), a new quinolone antibiotic, is reported to reduce CYP3A expression in the liver when administered to rats. The present study investigates whether the reduction in intestinal… (More)
- Takahiro Toda, Kanna Ohi, +4 authors Kiyoshi Sugiyama
- Yakugaku zasshi : Journal of the Pharmaceutical…
- 2009
We previously demonstrated that ciprofloxacin (CPX), a new quinolone antibiotic, suppresses Cyp3a in the mouse liver by reducing the hepatic level of lithocholic acid (LCA) produced by intestinal… (More)