Tomoyuki Watanabe

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Testicular testosterone produced during a critical perinatal period is thought to masculinize and defeminize the male brain from the inherent feminization program and induce male-typical behaviors in the adult. These actions of testosterone appear to be exerted not through its androgenic activity, but rather through its conversion by brain aromatase into(More)
In the present study, we examined the visual accommodation of subjects who were gazing fixedly at 3D images from two different displays: a cathode ray tube (CRT) while wearing special glasses and a liquid crystal display (LCD) while not wearing special glasses. The subjects in this experiment were two healthy people aged 22 and 39 years, all with normal(More)
The self-choice effect refers to the fact that self-chosen items are remembered better than experimenter-assigned items (Takahashi, 1991). The present study investigated the hypothesis that (a) response choice involves relational processing as activation of both target and context items, and (b) such activated context items are effective as potential(More)
In compliance with good manufacturing practice, the use of process analytical technology based on near-infrared spectroscopy requires that a calibration model be maintained to assure the continuous estimation accuracy. The present research proposes knowledge integration-based operationalization of calibration model maintenance. A model maintenance framework(More)
The mechanism by which adult neural stem cells (NSCs) are established during development is unclear. In this study, analysis of cell cycle progression by examining retention of a histone 2B (H2B)-GFP fusion protein revealed that, in a subset of mouse embryonic neural progenitor cells (NPCs), the cell cycle slows between embryonic day (E) 13.5 and E15.5(More)
We analyzed the results of the clock drawing test (CDT) in patients with Alzheimer's disease (AD) by quantitative and qualitative methods to evaluate its significance for cognitive function screening. We administered the CDT and mini-mental state examination (MMSE) to a total of 156 AD patients, and CDT performance was scored quantitatively in accordance(More)
The PTH receptor is to our knowledge one of the first G protein-coupled receptor (GPCR) found to sustain cAMP signaling after internalization of the ligand-receptor complex in endosomes. This unexpected model is adding a new dimension on how we think about GPCR signaling, but its mechanism is incompletely understood. We report here that endosomal(More)