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The morphogenesis of fungiform papillae occurs in a stereotyped pattern on the dorsal surface of the tongue in mice from embryonic day 12 (E12) to E17. The histological results and ultrastructural observations showed the development of specific structures in the epithelium into fungiform papillae. Prior to the morphological changes, the Bmp-4 and Shh(More)
OBJECTIVE The existence of mesenchymal stem cells (MSCs) in SF was previously reported. However, the behaviour and properties of MSCs derived from SF have not been fully elucidated. METHODS Human SFs were obtained from 19 knee joints with anterior cruciate ligament injury around the time of reconstruction surgery, and from three healthy volunteers. SF was(More)
INTRODUCTION Current cell therapy for cartilage regeneration requires invasive procedures, periosteal coverage and scaffold use. We have developed a novel transplantation method with synovial mesenchymal stem cells (MSCs) to adhere to the cartilage defect. METHODS For ex vivo analysis in rabbits, the cartilage defect was faced upward, filled with synovial(More)
The pes anserinus is composed of a combination of tendinous insertions of the sartorius, gracilis and semitendinosus muscles. Precise knowledge of the structures on the medial side of the knee and the relationships between fascia and tendons is critical for diagnosis, surgery, and the development of improved operative procedures of the knee. To obtain(More)
The meniscus is semilunar fibrocartilage, and its injury causes dysfunction of the knee. We previously reported a high chondrogenic potential of synovial mesenchymal stem cells (MSCs). Here, we examined whether intra-articular injected synovial MSCs adhered to the defect of the meniscus, survived there, and differentiated into cartilage cells. MSCs were(More)
INTRODUCTION We investigated the ability of a weekly intra-articular injection of bone morphogenetic protein (BMP)-7 to prevent osteoarthritis in rabbits with anterior cruciate ligament transections. METHODS First, 36 knee joints were randomly divided into four groups: 50, 500, 5,000 ng BMP-7, and control. Knee cartilage was evaluated at 4, 8, and 12(More)
BACKGROUND Though sera are essential for Mesenchymal stem cells (MSCs), the effect of heat-inactivation remains unknown. Autologous human serum is recommended for clinical use; however, it is unclear whether differentiation potentials are maintained. To examine whether heat-inactivation of serum affected the proliferation and whether autologous human serum(More)
INTRODUCTION Osteoarthritis is influenced by genetic and environment factors, including mechanical stress; however, the relationship between running and the development of osteoarthritis remains a matter of controversy. We investigated whether osteoarthritic change could be obtained in a rat strenuous running model, whether serum keratan sulfate in rats(More)
BACKGROUND Various findings in the lateral rotator interval to support the long head of the biceps tendon have been reported. The purpose of this study was to clarify the functional anatomy regarding the stabilization of the biceps tendon. MATERIAL AND METHODS Twenty embalmed shoulders were used for anatomic study, and 5 specimens of the anterosuperior(More)
The anatomy and function of the serratus anterior muscle and the long thoracic nerve have not been fully elucidated. The purposes of this investigation were (1) to clarify which nerve roots of the cervical spine supply each part of the muscle and contribute to the long thoracic nerve and (2) to investigate the anatomy of the 3 parts of the muscle to(More)