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Recently, the technique of system in package (SiP), in which a number of integrated circuit chips are enclosed in a single package, has been used for reducing size and supporting multiple functions. This has brought a number of benefits such as the shortening of development periods and the reduction of development costs compared to the technique of system(More)
BACKGROUND Neuroblastomas are characterized by hemizygous 1p deletions, suggesting that a tumor suppressor gene resides in this region. We previously mapped the smallest region of consistent deletion to a 2-Mb region of 1p36.31 that encodes 23 genes. Based on mutation analysis, expression pattern, and putative function, we identified CHD5 as the best tumor(More)
Approximately 20% of familial amyotrophic lateral sclerosis (FALS) arises from germ-line mutations in the superoxide dismutase-1 (SOD1) gene. However, the molecular mechanisms underlying the process have been elusive. Here, we show that a neuronal homologous to E6AP carboxyl terminus (HECT)-type ubiquitin-protein isopeptide ligase (NEDL1) physically binds(More)
This paper presents a nouet feed-through assignment algorithm based on minimum-cost multi-commodity flow formulation. After finding single-commodity flow with f70w conj%ts on the formulation, the algorithm eliminates all the conflicts to obtain a feasible solution. Since all nets and cell rows are considered simultaneously, our algorithm globally minimizes(More)
| This paper presents a novel method for logic minimization in large-scale multi-level networks. It accomplishes its great reductions on the basis of multi-signal implications and the relationships among these implications. Both are handled on a transitive implication graph, proposed in this paper, which realizes high-speed, high-quality minimization. This(More)
In patients with cancer and Parkinson's disease, the DJ-1 protein may be secreted into the serum during the impaired response of the underlying cell-protective mechanisms. In order to determine the clinical significance of DJ-1 protein in the sera of breast cancer patients, we examined blood samples from a breast cancer group (n = 180) and a non-cancerous(More)
Cardiac fibromas are rare benign tumors usually seen in the pediatric population. Generally, long-term survival after surgical resection is favorable, and recurrence of fibroma has been hardly reported. Herein, we report a case of a 34-year-old woman who presented with ventricular tachycardia 21 years after resection of a cardiac fibroma and was found to(More)
Many epidemiological studies have suggested that the recent increase in prevalence and severity of allergic diseases such as asthma is inversely correlated with Mycobacterium bovis bacillus Calmette Guerin (BCG) vaccination. However, the underlying mechanisms by which mycobacterial components suppress allergic diseases are not yet fully understood. Here we(More)
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