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BACKGROUND Neuroblastomas are characterized by hemizygous 1p deletions, suggesting that a tumor suppressor gene resides in this region. We previously mapped the smallest region of consistent deletion to a 2-Mb region of 1p36.31 that encodes 23 genes. Based on mutation analysis, expression pattern, and putative function, we identified CHD5 as the best tumor(More)
Recently, the technique of system in package (SiP), in which a number of integrated circuit chips are enclosed in a single package, has been used for reducing size and supporting multiple functions. This has brought a number of benefits such as the shortening of development periods and the reduction of development costs compared to the technique of system(More)
Approximately 20% of familial amyotrophic lateral sclerosis (FALS) arises from germ-line mutations in the superoxide dismutase-1 (SOD1) gene. However, the molecular mechanisms underlying the process have been elusive. Here, we show that a neuronal homologous to E6AP carboxyl terminus (HECT)-type ubiquitin-protein isopeptide ligase (NEDL1) physically binds(More)
We present a full superconformal tensor calculus in five spacetime dimensions in which the Weyl multiplet has 32 Bose plus 32 Fermi degrees of freedom. It is derived using dimensional reduction from the 6D superconformal tensor calculus. We present two types of 32+32 Weyl multiplets, a vector multiplet, linear multiplet, hypermultiplet and nonlinear(More)
This paper presents a nouet feed-through assignment algorithm based on minimum-cost multi-commodity flow formulation. After finding single-commodity flow with f70w conj%ts on the formulation, the algorithm eliminates all the conflicts to obtain a feasible solution. Since all nets and cell rows are considered simultaneously, our algorithm globally minimizes(More)
An off-shell formulation is given for the " supersymmetry in singular spaces " which has recently been developed in an on-shell formalism by Bergshoeff, Kallosh and Van Proeyen using supersymmetry singlet 'coupling constant' field and 4-form mul-tiplier field in five-dimensional space-time. We present this formulation for a general(More)
| This paper presents a novel method for logic minimization in large-scale multi-level networks. It accomplishes its great reductions on the basis of multi-signal implications and the relationships among these implications. Both are handled on a transitive implication graph, proposed in this paper, which realizes high-speed, high-quality minimization. This(More)
In patients with cancer and Parkinson's disease, the DJ-1 protein may be secreted into the serum during the impaired response of the underlying cell-protective mechanisms. In order to determine the clinical significance of DJ-1 protein in the sera of breast cancer patients, we examined blood samples from a breast cancer group (n = 180) and a non-cancerous(More)
Hypoxic induction of the early growth response-1 (Egr-1) transcription factor initiates proinflammatory and procoagulant gene expression. Orthotopic/isogeneic rat lung transplantation triggers Egr-1 expression and nuclear DNA binding activity corresponding to Egr-1, which leads to increased expression of downstream target genes such as interleukin-1β,(More)
BACKGROUND Congenital bicuspid aortic valve (CBAV) is the main cause of aortic stenosis (AS) in young adults. However, the histopathological features of AS in patients with CBAV have not been fully investigated. METHODS AND RESULTS We examined specimens of aortic valve leaflets obtained from patients who had undergone aortic valve re/placement at our(More)