Tomoyuki Esumi

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[reaction: see text] beta-Isocupreidine (beta-ICD)-catalyzed asymmetric Baylis-Hillman reactions of aromatic imines with 1,1,1,3,3,3-hexafluoroisopropyl acrylate (HFIPA) give (S)-enriched N-protected-alpha-methylene-beta-amino acid esters. In contrast to the corresponding aldehydes, imines show the opposite enantioselectivity. A mechanistic proposal(More)
[reaction: see text] The first total synthesis of (+/-)-trachyspic acid, a tumor cell heparanase inhibitor, was accomplished based on Cr(II)/Ni(II)-mediated reaction of the aldehyde containing the citric acid moiety and the long-chain triflate, and the relative configuration of this natural product was determined.
ring in Viburnum awabuki and V. odoratissimum from a phytochemical point of view. More than 30 kinds of vibsanetype diterpenes have been found so far, and they can be successfully categorized into three sub-classes. As part of our studies on biologically active compounds in Viburnum species, we have examined chemical components in the leaves of V.(More)
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