Tomoyasu Murakami

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Oxaliplatin, a platinum-based chemotherapy drug, frequently causes acute and chronic peripheral neuropathies including mechanical hyperalgesia. These adverse effects hinder anticancer therapy with the drug. In this study, we examined several drugs that might prevent oxaliplatin-induced peripheral neuropathy. Single intraperitoneal (i.p.) injection of(More)
Malnutrition is a common problem among cancer patients, affecting up to 85% of patients with certain cancers. In severe cases, malnutrition can progress to cachexia, a specific form of malnutrition characterized by loss of lean body mass and muscle wasting. Although this muscle wasting might be a product of enhanced protein degradation, the precise(More)
We studied the molecular mechanisms of the abnormal response of the beta-adrenergic receptor-adenylate cyclase system in the myocardium of spontaneously hypertensive rats (SHR) by ADP-ribosylation catalyzed by cholera toxin and pertussis toxin, by reconstitutive assay of cardiac membranes with the human platelet membranes, and by immunostaining with(More)
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