Tomoya Imanishi

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1. Intrathecal (i.t.) administration of nociceptin and high doses of morphine induced allodynia in response to innocuous tactile stimuli, and i.t. nociceptin evoked hyperalgesia in response to noxious thermal stimuli in conscious mice. Here we have characterized the nociceptin-induced allodynia and compared it with the morphine-induced allodynia and the(More)
The effects of ofloxacin (OFLX) and its isomers, levofloxacin (LVFX) and DR-3354, on the gamma-aminobutyric acid (GABA)-induced Cl- current in acutely dissociated rat hippocampal CA1 neurons were investigated using nystatin perforated patch recording configuration under voltage-clamp conditions. At 10(-5) M these 3 compounds themselves did not affect the(More)
The effects of 5 beta,3 alpha-pregnanolone (PGN) on gamma-aminobutyric acid (GABA)-induced Cl- current in acutely dissociated rat ventromedial hypothalamic neurons were investigated using the nystatin perforated patch recording mode under voltage-clamp conditions. The PGN at concentrations between 10(-7) and 10(-5) M evoked an inward current at a holding(More)
The interaction between the Ca(2+)-activated K+ currents (IK(Ca)) induced by acetylcholine (ACh), 1-aminocyclopentane-1S,3R-dicarboxylic acid (1S,3R)-ACPD) and caffeine in rat hippocampal CA1 neurones was investigated to examine the functional independence between IP3- and Ca(2+)-sensitive Ca2+ stores. Pretreatment with either ACh or (1S,3R)-ACPD almost(More)
As the molecular biology has made a rapid progress these years, there has bee n a g r eat number of changes required of the methodology for maintaining and utilizing DNA sequence data. For example, annotation to sequences has become complex and extensive. DDBJ which recognized the impending requirements decided to develop a new DNA sequence database system(More)
The combination of some fluorinated quinolone antimicrobials and certain non-steroidal anti-inflammatory drugs (NSAIDs), such as fenbufen, has been reported to elicit serious convulsions in humans. Fluoroquinolones, including norfloxacin (NFLX) and NSAIDs synergistically inhibit GABAA receptors. The mechanism(s) of the synergism, however, at present remains(More)
Due to the limited number of classroom activities on pronunciation, it is difficult for L2 learners to acquire the proper pronunciation of Japanese words. Moreover, because of the practical restrictions of classroom learning, the only way to improve learning efficiency is to automate utterance learning. However, the conventional self-learning method of(More)
Owing to the introduction of an energy-monitoring device called the "smart meter," a large amount of power-demand information regarding private houses is being stored around the world through the development of smart grids. Such electric consumption data include a variety of features related to the structure of the customer's home, as well as their family(More)
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