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In isolated chief cells from the guinea pig, cholecystokinin (10 nM) and a high concentration of ionomycin each caused a biphasic pattern of pepsinogen secretion. The initial fast response to(More)
In gastrin-stimulated, aequorin-loaded parietal cells from guinea pig gastric mucosa, a rapid but transient increase in the cytosolic free Ca2+ concentration ([Ca2+]i), owing to Ca2+ released from(More)
In 1822 cholera first arrived in Japan, but it did not reach Edo, which is the old name of Tokyo, nor Kanagawa, a prefecture located next to Tokyo. During a second epidemic in 1858, 30,000 or so(More)