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  • Tomoo Iwakuma, Guillermina Lozano
  • Biology, Medicine
  • Molecular cancer research : MCR
  • 2003 (First Publication: 1 December 2003)
  • The murine double minute 2 (mdm2) gene encodes a negative regulator of the p53 tumor suppressor. Amplification of mdm2 or increased expression by unknown mechanisms occurs in many tumors. Thus,Continue Reading
  • Kenichi Tanaka, Tomoo Iwakuma, Katsumi Harimaya, Hijiri Sato, Yoshiko Iwamoto
  • Biology, Medicine
  • The Journal of clinical investigation
  • 1997 (First Publication: 15 January 1997)
  • The translocation t(11;22) is a common chromosomal abnormality detected both in Ewing's sarcoma and in primitive neuroectodermal tumor cells. The translocation results in an EWS-Fli1 fusion gene,Continue Reading
  • Vinod Pant, Shunbin Xiong, Tomoo Iwakuma, Alfonso Quintás-Cardama, Guillermina Lozano
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 2011 (First Publication: 5 July 2011)
  • Mdm2 and Mdm4 are homologous RING domain-containing proteins that negatively regulate the tumor suppressor p53 under physiological and stress conditions. The RING domain of Mdm2 encodes anContinue Reading
  • Ruiying Zhao, Sai-Ching Jim Yeung, +19 authors Mong-Hong Lee
  • Medicine, Biology
  • The Journal of clinical investigation
  • 2011 (First Publication: 1 March 2011)
  • The mammalian constitutive photomorphogenesis 9 (COP9) signalosome (CSN), a protein complex involved in embryonic development, is implicated in cell cycle regulation and the DNA damage response. ItsContinue Reading