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A Novel Subunit Structure of Clostridium botulinum Serotype D Toxin Complex with Three Extended Arms*
A novel 14-mer subunit model for the botulinum toxin complex is proposed, which suggests how non-toxic components make up a “delivery vehicle” for BoNT.
HA-33 facilitates transport of the serotype D botulinum toxin across a rat intestinal epithelial cell monolayer.
The findings here indicate that all TCs can transport across the cell layer via a sialic acid-dependent process, and concludes that the HA-33/HA-17 arm is not necessarily required for, but facilitates, transport of botulinum toxin complexes.
Characterization of a Novel Acid Phosphatase from Embryonic Axes of Kidney Bean Exhibiting Vanadate-dependent Chloroperoxidase Activity*
Northern blot analysis demonstrated that the KeACP gene was expressed specifically in embryonic axes of the kidney bean, and its expression coincided with elongation of the embryonic axis during germination, and suggests that KeACP may play a role in modifying a wide variety of chlorinated compounds that are present in higher plants.
Role of nontoxic components of serotype D botulinum toxin complex in permeation through a Caco-2 cell monolayer, a model for intestinal epithelium.
It is concluded that the HA-33 subcomponent plays a critical role in the permeation of TCs into intestinal epithelium, and that other HA subcomponents protect BoNT against gastrointestinal digestion.
Roseibacterium elongatum gen. nov., sp. nov., an aerobic, bacteriochlorophyll-containing bacterium isolated from the west coast of Australia.
It is concluded that strain OCh 323T (=JCM 11220T=CIP 107377T) should be placed in a novel genus, Roseibacterium gen. nov., as the type strain of a novel species Roseib bacterium elongatum sp.nov.
Characterization of Toxin Complex Produced by a Unique Strain of Clostridium botulinum Serotype D 4947
A new method is established to separate the unique D-4947 NT from the complex, which will yield valuable information on structure of botulinum toxin, which is indistinguishable from the parent L-TC with respect to toxicity, hemagglutination activity and gel filtration profile.
Intraprostatic botulinum neurotoxin type a injection for benign prostatic hyperplasia: preliminary results with a newly purified neurotoxin.
Intraprostatic NTX injection induces prostate shrinkage and is effective in men with BPH and the PVR improved at 3 and 6 months post-treatment.