Tomonori Aoyama

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TGF-beta-activated kinase 1 (TAK1) is a MAP3K family member that activates NF-kappaB and JNK via Toll-like receptors and the receptors for IL-1, TNF-alpha, and TGF-beta. Because the TAK1 downstream molecules NF-kappaB and JNK have opposite effects on cell death and carcinogenesis, the role of TAK1 in the liver is unpredictable. To address this issue, we(More)
BACKGROUND & AIMS Development of nonalcoholic steatohepatitis (NASH) involves the innate immune system and is mediated by Kupffer cells and hepatic stellate cells (HSCs). Toll-like receptor 9 (TLR9) is a pattern recognition receptor that recognizes bacteria-derived cytosine phosphate guanine (CpG)-containing DNA and activates innate immunity. We(More)
Determining physical location of indoor objects is one of the key issues in development of context-aware applications in ubiquitous computing environment. This is mainly because context information obtained from sensor network is meaningful only when the physical location of context information source is determined. Recently, several indoor location(More)
Given the significant progress made and the continuing advances expected in the optical networking technology, it becomes attractive to build a future Optical Internet that natively supports bursty IP datagrams. Burst switching WDM optical networks are touted as suitable network architectures for future Optical Internet backbones. However, the lack of(More)
Massively multiplayer online games and other multi-user based networked applications are becoming a big business today. Such kind of technology has long been researched in the area called Networked Virtual Environments (Net-VE). With the recent deployment of broadband access technologies, the increase of the number of participants is putting pressure on the(More)
SIGNIFICANCE Hepatic fibrosis is the common pathophysiologic process resulting from chronic liver injury, characterized by the accumulation of an excessive extracellular matrix. Multiple lines of evidence indicate that oxidative stress plays a pivotal role in the pathogenesis of liver fibrosis. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase(More)
This document presents the conceptual design of a new generation network architecture. It is based on the discussions at 14 meetings and 2 seminars, which were held during an 11-month period beginning in May 2006 and attended primarily by the Network The future holds a computing environment characterized by embedded and pervasive computing and networking(More)
Chronic cholestasis often results in premature death from liver failure with fibrosis; however, the molecular mechanisms contributing to biliary cirrhosis are not demonstrated. In this article, we show that the death signal mediated by TNF-related apoptosis-inducing ligand (TRAIL) receptor 2/death receptor 5 (DR5) may be a key regulator of cholestatic liver(More)