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MicroRNA-9 Modulates Cajal–Retzius Cell Differentiation by Suppressing Foxg1 Expression in Mouse Medial Pallium
Vertebrate brain hosts a diverse collection of microRNAs, but little is known about their functions in vivo. Here we propose that mouse microRNA-9 (miR-9) targets Foxg1 mRNAs for proper generation ofExpand
Staphylococcus aureus–induced endothelial permeability and inflammation are mediated by microtubule destabilization
Staphylococcus aureus is a major etiological agent of sepsis and induces endothelial cell (EC) barrier dysfunction and inflammation, two major hallmarks of acute lung injury. However, the molecularExpand
Neural tube defects by NUAK1 and NUAK2 double mutation
Background: NUAK1 and NUAK2, members of the AMP‐activated protein kinase family of serine/threonine kinases, are prominently expressed in neuroectoderm, but their functions in neurulation have notExpand
Otx2 expression in anterior neuroectoderm and forebrain/midbrain is directed by more than six enhancers.
Otx2 plays essential roles in each site at each step of head development. We previously identified the AN1 enhancer at 91kb 5' upstream for the Otx2 expressions in anterior neuroectoderm (AN) atExpand
Evolutionary origin of the Otx2 enhancer for its expression in visceral endoderm.
In the mouse, the Otx2 gene has been shown to play essential roles in the visceral endoderm during anterior-posterior axis formation and head induction. While these are primary processes inExpand
Regulation of lung endothelial permeability and inflammatory responses by prostaglandin A2: role of EP4 receptor
PGA2 exhibits anti-inflammatory and barrier-protective effects on endothelial cells and in two mouse models of acute lung injury. PGA2-induced cytoskeletal remodeling and suppression of the NFκBExpand
Microtubule destabilization caused by particulate matter contributes to lung endothelial barrier dysfunction and inflammation.
Exposure to particulate matter (PM) associated with air pollution remains a major public health concern, as it has been linked to significant increase in cardiopulmonary morbidity and mortality. LungExpand
Role of End Binding Protein-1 in endothelial permeability response to barrier-disruptive and barrier-enhancing agonists.
Rapid changes in microtubule (MT) polymerization dynamics affect regional activity of small GTPases RhoA and Rac1, which play a key role in the regulation of actin cytoskeleton and endothelial cellExpand
A lineage specific enhancer drives Otx2 expression in teleost organizer tissues
In mouse Otx2 plays essential roles in anterior-posterior axis formation and head development in anterior visceral endoderm and anterior mesendoderm. The Otx2 expression in these sites is regulatedExpand
Role of truncated oxidized phospholipids in acute endothelial barrier dysfunction caused by particulate matter
Particulate matter (PM) air pollution is a global environmental health problem contributing to more severe lung inflammation and injury. However, the molecular and cellular mechanisms of PM-inducedExpand