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BACKGROUND Newer more advanced techniques in bronchoscopy may require longer procedure times, although a standard protocol for sedation during prolonged bronchoscopy has not yet been defined. METHODS We designed a prospective, non-randomized, single-arm study (UMIN trial number 000003971) using patient questionnaires and vital sign monitoring to assess(More)
Blind signal separation method is the method that the source signals are obtained by separating only the mixed signals. Generally, separation precision is lower when blind signal separation method is used for the sound signals. It is the cause that the power of the sound signals is concentrated in the low-frequency band. Specifically, the high-frequency(More)
BACKGROUND AND OBJECTIVE Bronchiolitis obliterans (BO) has been reported to develop following ingestion of Sauropus androgynus (SA), a leafy shrub distributed in Southeast Asia. Little is known about direct effects of SA on airway resident cells or haematopoietic cells in vitro. Identification of the SA component responsible for the development of BO would(More)
In recent years, genetic diagnostics of pathogenic splicing abnormalities are increasingly recognized as critically important in the clinical genetic diagnostics. It is reported that approximately 10% of pathogenic mutations causing human inherited diseases are splicing mutations. Nonetheless, it is still difficult to identify splicing abnormalities in(More)
OBJECTIVE Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive technique with a high diagnostic yield used in the investigation of mediastinal diseases including sarcoidosis. Although previous reports have discussed the echoic features of metastatic mediastinal lymph nodes in lung cancer, few have addressed(More)
There is the over-sampling method which is one of the methods for realizing the blind identification. In the conventional method, the unknown system is usually assumed by FIR system and the estimation filter is also used by FIR filter. However, if a target system has long impulse length in many real environment, we may have to assume IIR system for the(More)