Tomomi Metoki

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PURPOSE The Royal College of Surgeons (RCS) rat is the most extensively studied animal model for understanding the molecular pathology in inherited retinal degeneration, such as retinitis pigmentosa (RP). The purpose of the present study was to evaluate the pharmacologic effects of several Ca(2+) antagonists on the retinal degeneration of RCS rats. (More)
We report 3 cases of dural arteriovenous fistula (dAVF) with cortical venous reflux (CVR) presenting calcification in the cortico-medullary junction at the bottom of cerebral sulci on unenhanced CT. This likely results from chronic venous congestion with resulting impaired perfusion of the involved parenchyma. dAVF with CVR, which is known to have poor(More)
To examine rhodopsin (Rho) functions in P23H rat, kinetics of Rho regeneration and dephosphorylation were investigated by spectrophotometric analysis and immunofluorescence labeling method using specific antibodies toward phosphorylated 334Ser or 338Ser site. Rho dephosphorylation at both sites was extremely delayed in P23H retina as compared to normal(More)
PURPOSE The effects of various light-induced stresses on the retina were examined in the retinal degenerative rat model. METHODS Retinal morphology and electroretinograms (ERGs) were analyzed after application of light-induced stress of several intensities (650, 1300, 2500, or 5000 lux). For evaluation of rhodopsin (Rho) function, the kinetics of Rho(More)
PURPOSE To assess the long-term effects of nilvadipine on the progression of central visual field defect in retinitis pigmentosa (RP). METHODS Patients with RP were randomly divided into a treated group receiving oral nilvadipine and a control group. Progression of RP was evaluated with MD slope and the average sensitivity of the central 2° (ΔCENT4). (More)
PURPOSE To report a case of vitrectomy performed in a child with dense massive vitreous hemorrhage due to secondary acute myelogenous leukemia (AML) and tumor lysis syndrome. CASE A 4-year-old boy with clear-cell renal cell carcinoma was successfully treated with chemotherapy in 2011. However, in May 2012, he developed secondary AML. Although he was(More)
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