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Identification of Chondroitin Sulfate Glucuronyltransferase as Chondroitin Synthase-3 Involved in Chondroitin Polymerization
- Tomomi Izumikawa, Toshiyasu Koike, S. Shiozawa, K. Sugahara, J. Tamura, H. Kitagawa
- Chemistry, Medicine
- Journal of Biological Chemistry
- 25 April 2008
Recently, we demonstrated that chondroitin polymerization is achieved by any two combinations of human chondroitin synthase-1 (ChSy-1), ChSy-2 (chondroitin sulfate synthase 3, CSS3), and… Expand
Involvement of chondroitin sulfate synthase-3 (chondroitin synthase-2) in chondroitin polymerization through its interaction with chondroitin synthase-1 or chondroitin-polymerizing factor.
- Tomomi Izumikawa, T. Uyama, Yuka Okuura, K. Sugahara, H. Kitagawa
- Chemistry, Medicine
- The Biochemical journal
- 1 May 2007
Previously, we have demonstrated that co-expression of ChSy-1 (chondroitin synthase-1), with ChPF (chondroitin-polymerizing factor) resulted in a marked augmentation of glycosyltransferase activities… Expand
Correlation of C4ST-1 and ChGn-2 expression with chondroitin sulfate chain elongation in atherosclerosis.
- V. Anggraeni, N. Emoto, +5 authors K. Hirata
- Chemistry, Medicine
- Biochemical and biophysical research…
- 4 March 2011
Subendothelial retention of lipoproteins by proteoglycans (PGs) is the initiating event in atherosclerosis. The elongation of chondroitin sulfate (CS) chains is associated with increased low-density… Expand
Molecular Cloning of a Chondroitin Polymerizing Factor That Cooperates with Chondroitin Synthase for Chondroitin Polymerization*
- H. Kitagawa, Tomomi Izumikawa, T. Uyama, K. Sugahara
- Chemistry, Medicine
- Journal of Biological Chemistry
- 27 June 2003
We recently cloned human chondroitin synthase (ChSy) exhibiting the glucuronyltransferase-II (GlcATII) and N-acetylgalactosaminyltransferase-II (GalNAcTII) activities responsible for the biosynthesis… Expand
Identification of Phosphatase That Dephosphorylates Xylose in the Glycosaminoglycan-Protein Linkage Region of Proteoglycans*
- Toshiyasu Koike, Tomomi Izumikawa, Ban Sato, H. Kitagawa
- Chemistry, Medicine
- The Journal of Biological Chemistry
- 14 January 2014
Background: The enzyme responsible for the dephosphorylation of xylose in glycosaminoglycans remains unknown. Results: A protein that removed the phosphate from the phosphorylated linkage… Expand
Expression of rib-1, a Caenorhabditis elegans Homolog of the Human Tumor Suppressor EXT Genes, Is Indispensable for Heparan Sulfate Synthesis and Embryonic Morphogenesis*
- H. Kitagawa, Tomomi Izumikawa, +9 authors K. Sugahara
- Biology, Medicine
- Journal of Biological Chemistry
- 16 March 2007
The proteins encoded by all of the five cloned human EXT family genes (EXT1, EXT2, EXTL1, EXTL2, and EXTL3), members of the hereditary multiple exostoses gene family of tumor suppressors, are… Expand
FAM20B is a kinase that phosphorylates xylose in the glycosaminoglycan-protein linkage region.
- Toshiyasu Koike, Tomomi Izumikawa, J. Tamura, H. Kitagawa
- Biology, Medicine
- The Biochemical journal
- 15 July 2009
2-O-phosphorylation of xylose has been detected in the glycosaminoglycan-protein linkage region, GlcAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser, of proteoglycans. Recent mutant analyses in zebrafish… Expand
2-O-Phosphorylation of Xylose and 6-O-Sulfation of Galactose in the Protein Linkage Region of Glycosaminoglycans Influence the Glucuronyltransferase-I Activity Involved in the Linkage Region…
- Y. Tone, L. Pedersen, +6 authors K. Sugahara
- Chemistry, Medicine
- Journal of Biological Chemistry
- 13 June 2008
Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAβ1-3Galβ1-3Galβ1-4Xylβ1-O-Ser) of core… Expand
Chondroitin 4-O-Sulfotransferase-1 Regulates E Disaccharide Expression of Chondroitin Sulfate Required for Herpes Simplex Virus Infectivity*
- T. Uyama, Miho Ishida, +5 authors H. Kitagawa
- Biology, Medicine
- Journal of Biological Chemistry
- 15 December 2006
We have demonstrated a defect in expression of chondroitin 4-O-sulfotransferase-1 (C4ST-1) in murine sog9 cells, which are poorly sensitive to infection by herpes simplex virus type 1 (HSV-1). Sog9… Expand
Nematode Chondroitin Polymerizing Factor Showing Cell-/Organ-specific Expression Is Indispensable for Chondroitin Synthesis and Embryonic Cell Division*
- Tomomi Izumikawa, H. Kitagawa, +6 authors K. Sugahara
- Biology, Medicine
- Journal of Biological Chemistry
- 17 December 2004
Chondroitin polymerization was first demonstrated in vitro when human chondroitin synthase (ChSy) was coexpressed with human chondroitin polymerizing factor (ChPF), which is homologous to ChSy but… Expand