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The ClpXP ATP-Dependent Protease Regulates Flagellum Synthesis in Salmonella enterica Serovar Typhimurium
A new role is described in Salmonella enterica serovar Typhimurium in which ClpXP is involved in the regulation of flagellum synthesis and the DeltaflhD mutation abolished the enhanced effect by DeltaclpXP mutation on the production of flagingllar proteins.
Turnover of FlhD and FlhC, master regulator proteins for Salmonella flagellum biogenesis, by the ATP‐dependent ClpXP protease
The ClpXP protease family functions as a negative regulator for flagellar biogenesis in Salmonella and the cellular concentration of the FlhD2FlhC2 master regulator is tightly controlled at the post‐translational level by the Clp XP protease.
- Tomoko Yamamoto
- MedicineNihon rinsho. Japanese journal of clinical…
The ATP-Dependent Lon Protease of Salmonella enterica Serovar Typhimurium Regulates Invasion and Expression of Genes Carried on Salmonella Pathogenicity Island 1
- Akiko Takaya, T. Tomoyasu, Akane Tokumitsu, M. Morioka, Tomoko Yamamoto
- BiologyJournal of bacteriology
- 1 January 2002
It is found that the disruption of lon does not abolish the repression of hilA and sipC expression by high-oxygen or low-osmolarity conditions, suggesting that Lon represses SPI1 gene expression by a regulatory pathway independent of these environmental signals.
YdiV: a dual function protein that targets FlhDC for ClpXP‐dependent degradation by promoting release of DNA‐bound FlhDC complex
- Akiko Takaya, M. Erhardt, K. Karata, K. Winterberg, Tomoko Yamamoto, K. Hughes
- BiologyMolecular microbiology
- 1 March 2012
The results suggest that YdiV is an EAL‐like protein that has evolved from a dicyclic‐GMP phosphodiesterase into a dual‐function regulatory protein that connects flagellar gene expression to nutrient starvation.
Coordinated Regulation of Expression of Salmonella Pathogenicity Island 1 and Flagellar Type III Secretion Systems by ATP-Dependent ClpXP Protease
It is demonstrated that the expression of this complex of genes is repressed by the ATP-dependent ClpXP protease, which therefore suppresses macrophage apoptosis and coregulates SPI1-related virulence phenotypes and motility.
Negative Regulation of Quorum-Sensing Systems in Pseudomonas aeruginosa by ATP-Dependent Lon Protease
- Akiko Takaya, Fumiaki Tabuchi, Hiroko Tsuchiya, E. Isogai, Tomoko Yamamoto
- BiologyJournal of bacteriology
- 11 April 2008
It is demonstrated that Lon protease is involved in the regulation of quorum-sensing (QS) signaling systems in Pseudomonas aeruginosa, an opportunistic human pathogen.
Degradation of the HilC and HilD regulator proteins by ATP‐dependent Lon protease leads to downregulation of Salmonella pathogenicity island 1 gene expression
It is suggested that the regulation of SPI1 expression is negatively controlled through degradation of the HilC and HilD transcriptional regulators by Lon.
Molecular Typing of Japanese Field Isolates and Live Commercial Vaccine Strain of Mycoplasma synoviae Using Improved Pulsed-Field Gel Electrophoresis and vlhA Gene Sequencing
P pulsed-field gel electrophoresis (PFGE) and vlhA gene sequence analysis were applied and verified for typing the Mycoplasma synoviae live vaccine MS-H strain and field isolates from diseased chickens in Japan and generated unique fragment patterns in epidemiologically unrelated isolates.
Lon, a Stress-Induced ATP-Dependent Protease, Is Critically Important for Systemic Salmonella enterica Serovar Typhimurium Infection of Mice
The results suggest that the Lon protease is essentially involved in the systemic infection of mice with S. enterica serovar Typhimurium, which can be fatal, and the lon disruption mutant persists in the BALB/c mice for long periods without causing an overwhelming systemic infection.