Tomoko Osawa

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A conundrum of innate antiviral immunity is how nucleic acid-sensing Toll-like receptors (TLRs) and RIG-I/MDA5 receptors cooperate during virus infection. The conventional wisdom has been that the activation of these receptor pathways evokes type I IFN (IFN) responses. Here, we provide evidence for a critical role of a Toll-like receptor 3 (TLR3)-dependent(More)
Let La be a Bergman space. We are interested in an intermediate Hankel operator H M φ from La to a closed subspace M of L 2 which is invariant under the multiplication by the coordinate function z. It is well known that there do not exist any nonzero finite rank big Hankel operators, but we are studying same types in case H φ is close to big Hankel(More)
Hypertension is a typical modern lifestyle-related disease that is closely associated with the development of cardiovascular disorders. Elevation of angiotensin II (ANG II) is one of several critical factors for hypertension and heart failure; however, the mechanisms underlying the ANG II-mediated pathogenesis are still poorly understood. Here, we show that(More)
Let L2 = L2(D,r dr dθ/π) be the Lebesgue space on the open unit disc and let La = L2∩ ol(D) be the Bergman space. Let P be the orthogonal projection of L2 onto La and let Q be the orthogonal projection onto L̄ 2 a,0 = {g ∈ L2; ḡ ∈ La, g(0) = 0}. Then I−P ≥ Q. The big Hankel operator and the small Hankel operator on La are defined as: for φ in L∞, H big φ(More)
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