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A conundrum of innate antiviral immunity is how nucleic acid-sensing Toll-like receptors (TLRs) and RIG-I/MDA5 receptors cooperate during virus infection. The conventional wisdom has been that the activation of these receptor pathways evokes type I IFN (IFN) responses. Here, we provide evidence for a critical role of a Toll-like receptor 3 (TLR3)-dependent(More)
Hypertension is a typical modern lifestyle-related disease that is closely associated with the development of cardiovascular disorders. Elevation of angiotensin II (ANG II) is one of several critical factors for hypertension and heart failure; however, the mechanisms underlying the ANG II-mediated pathogenesis are still poorly understood. Here, we show that(More)
Let L 2 = L 2 (D, r dr dθ/π) be the Lebesgue space on the open unit disc and let L 2 a = L 2 ∩ Ᏼol(D) be the Bergman space. Let P be the orthogonal projection of L 2 onto L 2 a and let Q be the orthogonal projection onto ¯ L 2 a,0 = {g ∈ L 2 ; ¯ g ∈ L 2 a , g(0) = 0}. Then I − P ≥ Q. The big Hankel operator and the small Hankel operator on L 2 a are defined(More)
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